Volume 15, Number 2—February 2009
Research
Characteristics of 263K Scrapie Agent in Multiple Hamster Species
Kimberly D. Meade-White
, Kent D. Barbian, Brent Race, Cynthia Favara, Don Gardner, Lara Taubner, Stephen Porcella, and Richard Race
, Kent D. Barbian, Brent Race, Cynthia Favara, Don Gardner, Lara Taubner, Stephen Porcella, and Richard Race
Table
Average incubation period for 263K scrapie*
| Hamster species† | Cross-species 263K |
Second passage |
Third passage |
Back passage‡ |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Dpi ± SD | Titer/50 μL (1% BH) | Dpi | Titer/50 μL (1% BH) | Dpi | Titer/50 μL (1% BH) | Dpi | ||||
| Syrian | 85 | 2 x 109 | ND | ND | ND | ND | 79 ± 5 | |||
| Turkish | 91 ± 4.9 | 1 x 108.9 | 103 ± 7.2 | 1 x 106.7 | 85 ± 7.6 | 1 x 108.25 | 76 ± 0 | |||
| Djungarian | 155 ± 23.4 | 1 x 108.4 | 100 ± 9.0 | 1 x 109.6 | 99 ± 7.2 | 1 x 109.7 | 97 ± 7 | |||
| Siberian | 148 ± 26.5 | 1 x 108.3 | 117 ± 9.9 | 1 x107.75 | 114 ± 8.3 | 1 x 108.1 | 128 ± 17 | |||
| Chinese | 372 ± 29.1 | ND | 233 ± 17.9 | ND | 207 ± 15.2 | ND | 168 ± 7 | |||
| Armenian | 188 ± 10.4 | 1 x 107.35 | 156 ±4.8 | 1 x 107.75 | 145 ±7.5 | >1 x 108.5 | 145 ± 18 | |||
*Dpi, days postinoculation; ND, not done; BH, brain homogenate.
†16 hamsters/species.
‡In Syrian hamster.
Page created: December 08, 2010
Page updated: December 08, 2010
Page reviewed: December 08, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.