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Volume 15, Number 3—March 2009


Meeting the Challenge of Influenza Pandemic Preparedness in Developing Countries

David S. FedsonComments to Author 
Author affiliation: University of Virginia, Charlottesville, Virginia, USA (retired)

Main Article

Table 3

Research agenda to establish whether generic agents could be used for treatment and prophylaxis of a pandemic caused by a subtype H5N1-like influenza

1. Test candidate treatment regimens in mice, ferrets, and nonhuman primates to identify specific generic agents that might be effective in managing a pandemic
2. Study promising generic treatments in cell culture and animals to define the molecular mechanisms that explain their beneficial effects against influenza virus A (H5N1) and 1918-like influenza viruses
3. Conduct a global analysis to identify developing countries where these generic agents are produced and determine quantities produced, surge capacities, patterns of distribution, and costs to public programs
4. Establish an international process to coordinate or manage the stockpiling of generic agents and/or their distribution once a pandemic virus has emerged
5. Plan to conduct randomized controlled trials of promising generic treatments immediately after the emergence of a new pandemic virus

Main Article