Volume 15, Number 3—March 2009
Perspective
Meeting the Challenge of Influenza Pandemic Preparedness in Developing Countries
David S. Fedson
Table 3
Research agenda to establish whether generic agents could be used for treatment and prophylaxis of a pandemic caused by a subtype H5N1-like influenza
| 1. Test candidate treatment regimens in mice, ferrets, and nonhuman primates to identify specific generic agents that might be effective in managing a pandemic |
|---|
| 2. Study promising generic treatments in cell culture and animals to define the molecular mechanisms that explain their beneficial effects against influenza virus A (H5N1) and 1918-like influenza viruses |
| 3. Conduct a global analysis to identify developing countries where these generic agents are produced and determine quantities produced, surge capacities, patterns of distribution, and costs to public programs |
| 4. Establish an international process to coordinate or manage the stockpiling of generic agents and/or their distribution once a pandemic virus has emerged |
| 5. Plan to conduct randomized controlled trials of promising generic treatments immediately after the emergence of a new pandemic virus |
Page created: December 07, 2010
Page updated: December 07, 2010
Page reviewed: December 07, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.