Volume 15, Number 6—June 2009
Dispatch
Japanese Encephalitis Viruses from Bats in Yunnan, China
Table 2
Comparison of key amino acid residues of the E protein of Japanese encephalitis virus important for neurovirulence*
Strain | E107 | E138 | E176 | E177 | E264 | E279 | E315 | E439 |
---|---|---|---|---|---|---|---|---|
SA14-14-2 | Phe | Lys | Val | Ala | His | Met | Val | Arg |
B58 | Leu | Glu | Ile | Thr | Gln | Lys | Ile | Lys |
GB30 | Leu | Glu | Ile | Thr | Gln | Lys | Ile | Lys |
Nakayama | Leu | Glu | Ile | Thr | Gln | Lys | Ile | Lys |
*These 8 aa residues of the envelope protein are shown to play a key role in neurovirulence. They vary substantially between the attenuated vaccine strain (SA14-14-2) and the virulent strain (Nakayama).