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Volume 15, Number 7—July 2009
Dispatch

Rickettsia slovaca and R. raoultii in Tick-borne Rickettsioses

Philippe Parola, Clarisse Rovery, Jean Marc Rolain, Philippe Brouqui, Bernard Davoust, and Didier RaoultComments to Author 
Author affiliations: Unité des Rickettsies, Marseille, France (P. Parola, C. Rovery, J.M. Rolain, P. Brouqui, D. Raoult); Direction Régionale du Service de Santé des Armées, Toulon, France (B. Davoust)

Main Article

Table

Characteristics of TIBOLA/DEBONEL patients with certain or probable Rickettsia slovaca infection compared with patients with certain or probable R. raoultii infection*

Characteristic TIBOLA/DEBONEL patients, n = 86
No. R. slovaca infections (%), n = 49†‡ No. R. raoultii infections (%), n = 7† p value
Female sex 33/49 (67) 7/7 (100) 0.04
Mean age, y 32 32 0.90
Age <12 y 20/49 (41) 3/7 (43) 0.46
Hiking or recreational activities such as a walk in the forest 21/28 (75) 4/5 (80) 0.44
Fever§ 21/39 (54) 4/5 (80) 0.27
Painful eschar 14/22 (64) 3/3 (100) 0.30
Painful adenopathies 18/26 (69) 5/5 (100) 0.20
Face edema 6/31 (19) 2/5 (40) 0.30
Rash 7/30 (23) 1/5 (20) 0.68
Headache 16/30 (53) 4/4 (100) 0.10
Alopecia 16/27 (59) 0/4 0.09
Asthenia 23/33 (70) 5/5 (100) 0.20
Prolonged asthenia¶ 10/29 (35) 2/4 (50) 0.46
Chronic asthenia# 4/28 (14) 1/4 (25) 0.51

*Certain cases were those with positive culture, PCR, or suicide PCR results in blood or skin biopsy samples or with lymph node aspirates. Probable cases were those with identification by PCR and sequencing of the corresponding Rickettsia spp. in ticks, Western blot results demonstrating R. slovaca– or R. raoultii–specific antibodies, or a cross-absorption assay demonstrating specific antibodies against R. slovaca or R. raoultii. TIBOLA, tick-borne lymphadenopathy; DEBONEL, Dermacentor-borne necrosis erythema and lymphadenopathy.
†Denominators indicate the number of patients for whom the criterion was available.
‡Includes 14 patients previously reported (7).
§Temperature >37°5C.
¶Self-reported, persistent asthenia of 1 to 6 months.
#Self-reported persistent or relapsing asthenia of >6 consecutive months.

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References
  1. Parola  P, Paddock  C, Raoult  D. Tick-borne rickettsioses around the world: emerging diseases challenging old concepts. Clin Microbiol Rev. 2005;18:719–56. DOIPubMed
  2. Raoult  D, Berbis  P, Roux  V, Xu  W, Maurin  M. A new tick-transmitted disease due to Rickettsia slovaca. Lancet. 1997;350:112–3. DOIPubMed
  3. Raoult  D, Lakos  A, Fenollar  F, Beytout  J, Brouqui  P, Fournier  PE. Spotless rickettsiosis caused by Rickettsia slovaca and associated with Dermacentor ticks. Clin Infect Dis. 2002;34:1331–6. DOIPubMed
  4. Mediannikov  O, Matsumoto  K, Samoylenko  I, Drancourt  M, Roux  V, Rydkina  E, Rickettsia raoultii sp. nov., a spotted fever group rickettsia associated with Dermacentor ticks in Europe and Russia. Int J Syst Evol Microbiol. 2008;58:1635–9. DOIPubMed
  5. Ibarra  V, Oteo  JA, Portillo  A, Santibanez  S, Blanco  JR, Metola  L, Rickettsia slovaca infection: DEBONEL/TIBOLA. Ann N Y Acad Sci. 2006;1078:206–14. DOIPubMed
  6. Parola  P, Vestris  G, Martinez  D, Brochier  B, Roux  V, Raoult  D. Tick-borne rickettiosis in Guadeloupe, the French West Indies: isolation of Rickettsia africae from Amblyomma variegatum ticks and serosurvey in humans, cattle, and goats. Am J Trop Med Hyg. 1999;60:888–93.PubMed
  7. Gouriet  F, Rolain  JM, Raoult  D. Rickettsia slovaca infection, France. Emerg Infect Dis. 2006;12:521–3.PubMed
  8. Tissot-Dupont  H, Raoult  D. Q fever. Infect Dis Clin North Am. 2008;22:505–14. DOIPubMed
  9. Estrada-Pena  A, Bouattour  A, Camicas  JL, Walker  AR. Ticks of domestic animals in the Mediterranean region. Zaragoza (Spain): University of Zaragoza; 2004.
  10. Ibarra  V, Portillo  A, Santibanez  S, Blanco  JR, Perez-Martinez  L, Marquez  J, DEBONEL/TIBOLA: is Rickettsia slovaca the only etiological agent? Ann N Y Acad Sci. 2005;1063:346–8. DOIPubMed
  11. Marquez  FJ, Rojas  A, Ibarra  V, Cantero  A, Rojas  J, Oteo  JA, Prevalence data of Rickettsia slovaca and other SFG rickettsiae species in Dermacentor marginatus in the southeastern Iberian peninsula. Ann N Y Acad Sci. 2006;1078:328–30. DOIPubMed
  12. Dautel  H, Dippel  C, Oehme  R, Hartelt  K, Schettler  E. Evidence for an increased geographical distribution of Dermacentor reticulatus in Germany and detection of Rickettsia sp. RpA4. Int J Med Microbiol. 2006;296:149–56. DOIPubMed
  13. Vitorino  L, De  SR, Bacellar  F, Ze-Ze  L. Rickettsia sp. strain RpA4 detected in Portuguese Dermacentor marginatus ticks. Vector Borne Zoonotic Dis. 2007;7:217–20. DOIPubMed
  14. Nijhof  AM, Bodaan  C, Postigo  M, Nieuwenhuijs  H, Opsteegh  M, Franssen  L, Ticks and associated pathogens collected from domestic animals in the Netherlands. Vector Borne Zoonotic Dis. 2007;7:585–95. DOIPubMed
  15. Marquez  FJ. Spotted fever group Rickettsia in ticks from southeastern Spain natural parks. Exp Appl Acarol. 2008;45:185–94. DOIPubMed

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