Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link

Volume 15, Number 9—September 2009

Dispatch

Merkel Cell Polyomavirus DNA in Persons without Merkel Cell Carcinoma

Ulrike WielandComments to Author , Cornelia Mauch, Alexander Kreuter, Thomas Krieg, and Herbert Pfister
Author affiliations: Institute of Virology, Koeln, Germany (U. Wieland, H. Pfister); Department of Dermatology, Koeln (C. Mauch, T. Krieg); Department of Dermatology, Bochum, Germany (A. Kreuter)

Main Article

Table 1

MCPyV DNA in biopsies of immunocompetent patients without MCC*

Histologic diagnosis No. samples No. (%) MCPyV-positive by nested PCR
Papilloma/wart 4 0 (0)
Actinic keratosis 7 0 (0)
Keratoacanthoma 7 3 (43)
Squamous cell carcinoma 6 1 (17)
Bowen disease/carcinoma 4 1 (25)
Basal cell carcinoma 21 3 (14)
Malignant melanoma 12 2 (17)
All skin tumors 61 10 (16)
Perilesional healthy skin 34 8 (24)

*MCPyV, Merkel cell polyomavirus; MCC, Merkel cell carcinoma. All samples shown were negative for Merkel cell polyomavirus in single-round PCR. Six MCPyV-positive perilesional samples had an MCPyV-positive lesional counterpart (3 basal cell carcinomas, 2 keratoacanthomas, 1 squamous cell carcinoma); 1 MCPyV-positive perilesional biopsy had a MCPyV-negative counterpart (basal cell carcinoma); and of 1 MCPyV-positive perilesional biopsy the lesional counterpart was not available. For origin of samples see (7).

Main Article

References
  1. Feng  H, Shuda  M, Chang  Y, Moore  PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319:1096–100. DOIPubMedGoogle Scholar
  2. Becker  JC, Houben  R, Ugurel  S, Trefzer  U, Pfohler  C, Schrama  D. MC polyomavirus Is frequently present in Merkel cell carcinoma of European patients. J Invest Dermatol. 2009;129:248–50. DOIPubMedGoogle Scholar
  3. Foulongne  V, Kluger  N, Dereure  O, Brieu  N, Guillot  B, Segondy  M. Merkel cell polyomavirus and Merkel cell carcinoma, France. Emerg Infect Dis. 2008;14:1491–3. DOIPubMedGoogle Scholar
  4. Garneski  KM, Warcola  AH, Feng  Q, Kiviat  NB, Leonard  JH, Nghiem  P. Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. J Invest Dermatol. 2009;129:246–8. DOIPubMedGoogle Scholar
  5. Kassem  A, Schopflin  A, Diaz  C, Weyers  W, Stickeler  E, Werner  M, Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res. 2008;68:5009–13. DOIPubMedGoogle Scholar
  6. Ridd  K, Yu  S, Bastian  BC. The presence of polyomavirus in non-melanoma skin cancer in organ transplant recipients is rare. J Invest Dermatol. 2009;129:250–2. DOIPubMedGoogle Scholar
  7. Weissenborn  SJ, Nindl  I, Purdie  K, Harwood  C, Proby  C, Breuer  J, Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancers. J Invest Dermatol. 2005;125:93–7. DOIPubMedGoogle Scholar
  8. Kreuter  A, Brockmeyer  NH, Weissenborn  SJ, Gambichler  T, Stucker  M, Altmeyer  P, Penile intraepithelial neoplasia is frequent in HIV-positive men with anal dysplasia. J Invest Dermatol. 2008;128:2316–24. DOIPubMedGoogle Scholar
  9. Kreuter  A, Hochdorfer  B, Brockmeyer  NH, Altmeyer  P, Pfister  H, Wieland  U. A human papillomavirus-associated disease with disseminated warts, depressed cell-mediated immunity, primary lymphedema, and anogenital dysplasia: WILD syndrome. Arch Dermatol. 2008;144:366–72. DOIPubMedGoogle Scholar
  10. Weissenborn  SJ, De Koning  MN, Wieland  U, Quint  WG, Pfister  HJ. Intrafamilial transmission and family-specific spectra of cutaneous beta-papillomaviruses. J Virol. 2009;83:811–6. DOIPubMedGoogle Scholar
  11. Palefsky  J. Human papillomavirus-related tumors in HIV. Curr Opin Oncol. 2006;18:463–8. DOIPubMedGoogle Scholar
  12. Sharp  CP, Norja  P, Anthony  I, Bell  JE, Simmonds  P. Reactivation and mutation of newly discovered WU, KI, and Merkel cell carcinoma polyomaviruses in immunosuppressed individuals. J Infect Dis. 2009;199:398–404. DOIPubMedGoogle Scholar
  13. Moll  I, Moll  R. Early development of human Merkel cells. Exp Dermatol. 1992;1:180–4. DOIPubMedGoogle Scholar
  14. Narisawa  Y, Hashimoto  K, Nakamura  Y, Kohda  H. A high concentration of Merkel cells in the bulge prior to the attachment of the arrector pili muscle and the formation of the perifollicular nerve plexus in human fetal skin. Arch Dermatol Res. 1993;285:261–8. DOIPubMedGoogle Scholar
  15. Boxman  IL, Berkhout  RJ, Mulder  LH, Wolkers  MC, Bouwes Bavinck  JN, Vermeer  BJ, Detection of human papillomavirus DNA in plucked hairs from renal transplant recipients and healthy volunteers. J Invest Dermatol. 1997;108:712–5. DOIPubMedGoogle Scholar

Main Article

Page created: December 07, 2010
Page updated: December 07, 2010
Page reviewed: December 07, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external