Volume 15, Number 9—September 2009
Merkel Cell Polyomavirus DNA in Persons without Merkel Cell Carcinoma
|Histologic diagnosis||No. samples||No. (%) MCPyV-positive by nested PCR|
|Actinic keratosis||7||0 (0)|
|Squamous cell carcinoma||6||1 (17)|
|Bowen disease/carcinoma||4||1 (25)|
|Basal cell carcinoma||21||3 (14)|
|Malignant melanoma||12||2 (17)|
|All skin tumors||61||10 (16)|
|Perilesional healthy skin||34||8 (24)|
*MCPyV, Merkel cell polyomavirus; MCC, Merkel cell carcinoma. All samples shown were negative for Merkel cell polyomavirus in single-round PCR. Six MCPyV-positive perilesional samples had an MCPyV-positive lesional counterpart (3 basal cell carcinomas, 2 keratoacanthomas, 1 squamous cell carcinoma); 1 MCPyV-positive perilesional biopsy had a MCPyV-negative counterpart (basal cell carcinoma); and of 1 MCPyV-positive perilesional biopsy the lesional counterpart was not available. For origin of samples see (7).
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