Volume 15, Number 9—September 2009
Dispatch
Human Plasmodium knowlesi Infection Detected by Rapid Diagnostic Tests for Malaria
Jaap J. van Hellemond, Marijke Rutten, Rob Koelewijn, Anne-Marie Zeeman, Jaco J. Verweij, Pieter J. Wismans, Clemens H. Kocken, and Perry J.J. van Genderen
Table
Evaluation of 2 commercially available rapid diagnostic antigen tests used for detection of Plasmodium knowlesi*
| Time after admission, h | P. knowlesi parasitemia, trophozoites/μL | BinaxNow† |
Diamed OptiMAL‡ |
|||
|---|---|---|---|---|---|---|
| HRP-2 | Aldolase | P. falciparum–LDH | Pan-malarial LDH | |||
| 0 | 84,000 | –§ | +§ | + | + | |
| 16 | 1,587 | –§ | –§ | + | + | |
| 24 | 138 | – | – | – | – | |
| 40 | ND | – | – | – | – | |
*HRP-2, histidine-rich protein 2; LDH, lactate dehydrogenase; ND, not detectable. All tests were performed on blood samples collected in EDTA and frozen at –20°C for 2 weeks.
†Binax, Inc., Scarborough, ME, USA.
‡Diamed, Cressler, Switzerland.
§Tests were also performed on freshly collected blood samples; results were identical.
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