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Volume 15, Number 9—September 2009


Human Plasmodium knowlesi Infection Detected by Rapid Diagnostic Tests for Malaria

Jaap J. van Hellemond, Marijke Rutten, Rob Koelewijn, Anne-Marie Zeeman, Jaco J. Verweij, Pieter J. Wismans, Clemens H. Kocken, and Perry J.J. van GenderenComments to Author 
Author affiliations: Erasmus University Medical Center, Rotterdam, the Netherlands (J.J. van Hellemond); Harbour Hospital and Institute of Tropical Diseases, Rotterdam (M. Rutten, R. Koelewijn, P.J. Wismans, P.J.J. van Genderen); Biomedical Primate Research Centre, Rijswijk, the Netherlands (A.-M. Zeeman, C.H. Klocken); Leiden University Medical Center, Leiden, the Netherlands (J.J. Verweij)

Main Article


Evaluation of 2 commercially available rapid diagnostic antigen tests used for detection of Plasmodium knowlesi*

Time after admission, h P. knowlesi parasitemia, trophozoites/μL BinaxNow†

Diamed OptiMAL‡
HRP-2 Aldolase P. falciparum–LDH Pan-malarial LDH
0 84,000 –§ + +
16 1,587 –§ –§ + +
24 138
40 ND

*HRP-2, histidine-rich protein 2; LDH, lactate dehydrogenase; ND, not detectable. All tests were performed on blood samples collected in EDTA and frozen at –20°C for 2 weeks.
†Binax, Inc., Scarborough, ME, USA.
‡Diamed, Cressler, Switzerland.
§Tests were also performed on freshly collected blood samples; results were identical.

Main Article