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Volume 16, Number 6—June 2010


Xenotropic Murine Leukemia Virus–related Gammaretrovirus in Respiratory Tract

Nicole FischerComments to Author , Claudia Schulz, Kristin Stieler, Oliver Hohn, Christoph Lange, Sung Sup Park, and Martin Aepfelbacher
Author affiliations: University Medical Center Hamburg-Eppendorf, Hamburg, Germany (N. Fischer, C. Schulz, K. Stieler, M. Aepfelbacher); Robert Koch-Institute, Berlin, Germany (O. Hohn); Leibniz-Center for Medicine and Biosciences, Borstel, Germany (C. Lange); University of Bonn Medical Centre, Bonn, Germany (C. Drosten)

Main Article


Detection of XMRV in respiratory tract secretions from 329 persons*

Group Patient median age, y Underlying disease Sample XMRV+
1 (75 patients with RTI) 42 None Sputum, nasal swab 3/75 (2.3%)
2 (31 patients with RTI) 60 COPD BAL 1/31 (3.2%)
3 (161 patients with RTI) 32 Immunosuppression after SOT or BMT BAL, TS 16/161 (9.9%)
Control (62 persons with no RTI) 35 None BAL, throat swab 2/62 (3.2%)

*XMRV, xenotropic murine leukemia virus; +, positive for XMRV–specific sequences by PCR; RTI, respiratory tract infection; COPD, chronic obstructive pulmonary disease; BAL, bronchoalveolar lavage; SOT, solid organ transplantation; BMT, bone marrow transplantation; TS, tracheal secretion.

Main Article