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Volume 16, Number 7—July 2010
Synopsis

Oseltamivir Resistance in Adult Oncology and Hematology Patients Infected with Pandemic (H1N1) 2009 Virus, Australia

Adrian R. TramontanaComments to Author , Biju George, Aeron C. Hurt, Joseph S. Doyle, Katherine Langan, Alistair B. Reid, Janet M. Harper, Karin Thursky, Leon J. Worth, Dominic E Dwyer, C. Orla Morrissey, Paul D.R. Johnson, Kirsty L. Buising, Simon James Harrison, John F. Seymour, Patricia E. Ferguson, Bin Wang, Justin T. Denholm, Allen C. Cheng, and Monica Slavin
Author affiliations: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (A.R. Tramontana, K. Thursky, L.J. Worth, S.J. Harrison, J.F. Seymour, M. Slavin); Western Hospital, Footscray, Victoria, Australia (A.R. Tramontana); Westmead Hospital, Sydney, New South Wales, Australia (B. George, D.E. Dwyer, B. Wang), World Health Organization Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia (A.C. Hurt); The Alfred Hospital, Prahran, Victoria, Australia (J.S. Doyle, C.O. Morrissey); Austin Health, Heidelberg, Victoria, Australia (K. Langan, P.D.R. Johnson); St. Vincent’s Hospital, Melbourne, Victoria, Australia (A.B. Reid, K.L. Buising); Royal Melbourne Hospital, Melbourne (J.M. Harper, J.T. Denholm, M. Slavin); Centre for Infectious Diseases and Microbiology, Sydney (P.E. Ferguson); Monash University, Prahran (A.C. Cheng)

Main Article

Table 1

Demographics and clinical findings among patients who had malignancy or HSCT and influenza A pandemic (H1N1) 2009 virus, Australia*

Patient no. Age, y/sex Underlying malignancy Coexisting conditions Acquisition Radiographic infiltrates ICU Death
Allogeneic stem cell transplant recipients
1 44/F Prolymphocytic leukemia GVHD, renal Community† None Yes Yes
2 53/F Non-Hodgkin lymphoma GVHD‡ Nosocomial Multifocal Yes Yes
3 33/M Hodgkin lymphoma None Community None No No
4 57/F CML GVHD§ Community Unifocal No No
5 61/M Myelodysplastic syndrome None Nosocomial Multifocal Yes Yes
6 56/M Myelofibrosis GVHD‡ Community Multifocal Yes Yes
7 61/M AML GVHD,§ cardiac Community None No No
8
 63/F
 AML
 None
 Nosocomial
 Unifocal
 Yes
 No
Autologous stem cell transplant recipients
9 70/M Multiple myeloma Pulmonary Community† Unifocal Yes No
10 50/F Multiple myeloma None Community Multifocal Yes Yes
11 72/M Multiple myeloma Type 2 diabetes Community None No No
12 42/F Multiple myeloma Type 2 diabetes Community Multifocal Yes No
13 57/M Multiple myeloma None Community† Multifocal No No
14 30/F Hodgkins lymphoma None Community Multifocal No No
15 52/F Non-Hodgkins lymphoma None Community None No No
16
 68/M
 Multiple myeloma
 Renal
 Community
 Multifocal
 Yes
 Yes
Patients with no prior stem cell transplant
17 24/F Hodgkins lymphoma None Community¶ None No No
18 72/M AML Type 2 diabetes Community Multifocal No No
19 63/F Multiple myeloma None Community Multifocal No No
20 80/F Aplastic anemia Cardiac Community None No No
21 70/F Hodgkins lymphoma None Community None No No
22 61/F CLL None Community† Multifocal No No
23 63/F Non-Hodgkin lymphoma Pulmonary Community† None No No
24 68/M CLL Pulmonary Community None Yes Yes
25 76/M CLL Pulmonary Community Multifocal No No
26 59/F AML None Community None No No
27 47/F CLL None Community No imaging No No
28 57/M Multiple myeloma None Community Unifocal No No
29 56/M Hodgkin lymphoma Type 2 diabetes Community Multifocal No No
30 26/M ALL None Nosocomial No imaging No No
31 55/F Cervical cancer None Community None No No
32 50/F Breast cancer None Community Multifocal No No

*HSCT, hematopoietic stem cell transplant; ICU, intensive care unit; GVHD, graft-versus-host disease; CML, chronic myeloid leukemia; AML, acute myeloid leukemia; CLL, chronic lymphocytic leukemia; ALL, acute lymphocytic leukemia.
†Household contacts with influenza-like illness identified.
‡Severe GVHD.
§Chronic GVHD.
¶Patient 17 had onset of influenza-like symptoms on returning to Victoria from interstate travel.

Main Article

Page created: March 02, 2011
Page updated: March 02, 2011
Page reviewed: March 02, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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