Volume 17, Number 1—January 2011
Dispatch
New Delhi Metallo-β-Lactamase in Klebsiella pneumoniae and Escherichia coli, Canada
Michael R. Mulvey
, Jennifer M. Grant, Katherine Plewes, Diane Roscoe, and David A. Boyd
, Jennifer M. Grant, Katherine Plewes, Diane Roscoe, and David A. Boyd
Table 2
Antimicrobial drug susceptibilities of the isolates from study of New Delhi metallo-β-lactamase in Klebsiella pneumoniae and Escherichia coli, Canada, 2010*
| Test/antimicrobial agent | K. pneumoniae N10–0469 | E. coli DH10B (pNDM-Kp10469) | E. coli N10–0505 | E. coli DH10B (pNDM-Ec10505) | E. coli DH10B |
|---|---|---|---|---|---|
| Broth microdilution (MIC, μg/mL) | |||||
| Amoxicillin/clavulanic acid | >32 | >32 | 32 | >32 | 4 |
| Piercillin/tazobactam | >64 | >64 | >64 | >64 | <4 |
| Ampicillin | >16 | >16 | >16 | >16 | 2 |
| Cefazolin | >16 | >16 | >16 | >16 | <8 |
| Cefotaxime | >64 | >64 | >64 | >64 | <0.25 |
| Cefotaxime/clavulanic acid | >64 | >64 | >64 | >64 | <0.12 |
| Ceftazidime | >128 | >128 | >128 | >128 | <0.25 |
| Ceftazidime/clavulanic acid | >128 | >128 | >128 | >128 | 0.25 |
| Cefepime | >16 | 16 | >16 | 16 | <1 |
| Cefoxitin | >64 | >64 | >64 | >64 | 8 |
| Imipenem | >16 | 4 | 2 | 2 | <0.5 |
| Meropenem | >8 | 2 | 8 | 2 | <1 |
| Chloramphenicol | 16 | 4 | 32 | 4 | <2 |
| Tetracycline | >32 | ≤4 | 32 | ≤4 | <4 |
| Amikacin | >64 | >64 | >64 | >64 | 2 |
| Gentamicin | >16 | >16 | >16 | >16 | <0.25 |
| Ciprofloxacin | >2 | <0.015 | >2 | <0.015 | <0.015 |
| Trimethoprim/sulfamethoxazole |
>4 |
<0.12 |
>4 |
<0.12 |
<0.12 |
| Etest (MIC, μg/mL) | |||||
| Aztreonam | >256 | 4 | >256 | 4 | 0.094 |
| Imipenem | >32 | 4 | >32 | 4 | 0.19 |
| Meropenem | >32 | 8 | 32 | 6 | 0.032 |
| Ertapenem | >32 | 16 | >32 | 16 | 0.008 |
| Colistin | 0.38 | ND | 0.38 | ND | ND |
| Polymyxin B | 0.19 | ND | 0.25 | ND | ND |
| Tigecycline |
1.5 |
ND |
0.125 |
ND |
ND |
| Disk diffusion (zone diameter, mm) | |||||
| Imipenem | 6 | 14 | 11 | 13 | 33 |
| Meropenem | 6 | 15 | 10 | 14 | 35 |
| Ertapenem | 6 | 13 | 6 | 13 | 35 |
*NDM, New Delhi metallo-β-lactamase; ND, not done.
Page created: July 08, 2011
Page updated: July 08, 2011
Page reviewed: July 08, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
Content Credential