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Volume 17, Number 12—December 2011

Research

Hepatitis E Virus in Rats, Los Angeles, California, USA

Robert H. Purcell, Ronald E. Engle, Michael P. Rood, Yamina Kabrane-Lazizi1, Hanh T. Nguyen, Sugantha Govindarajan, Marisa St. Claire2, and Suzanne U. EmersonComments to Author 
Author affiliations: National Institutes of Health, Bethesda Maryland, USA (R.H. Purcell, R.E. Engle, Y. Kabrane-Lazizi, H.T. Nguyen, S.U. Emerson); Department of Public Health Services, Los Angeles, California, USA (M.P. Rood); Rancho Los Amigos Hospital, Downey, California, USA (S. Govindarajan); Bioqual, Inc., Rockville, Maryland, USA (M. St. Claire)

Main Article

Table 3

Titers for HEV in samples from laboratory rats, Los Angeles, California, USA*

Sample type and source log10 ID50 log10 RT-PCR50
Feces
Rat B76† <1 3.4
Rat B84†
 <1
 3.4
Intestinal contents: Rat B182
Small intestine <3 4.9
Cecum <3 5.4
Colon
 <3
 4.9
Serum
Rat B182 ND 3.7
Rat B300 ND <2.2
Rat B350
 3.7
 4.7
Liver
Rat B182 4.7 7.2
Rat B300 4.2 5.7
Rat B350 6.2 7.7

*Values are per milliliter or per gram. HEV, hepatitis E virus; ID50, 50% infectious dose; RT-PCR50, 50% reverse transcription PCR titer; ND, not determined.
†Serum from wild rats was injected into laboratory rats B76 and B84. Samples from these 2 rats were serially passaged into other laboratory rats (wild rat → rat B76 → rat B300; wild rat → rat B84 → rat B182 → rat B350).

Main Article

1Current affiliation: Embassy of France, Beijing, People’s Republic of China.

2Current affiliation: National Institutes of Health, Frederick, Maryland, USA.

Page created: November 30, 2011
Page updated: November 30, 2011
Page reviewed: November 30, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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