Volume 17, Number 12—December 2011
Research
Hepatitis E Virus in Rats, Los Angeles, California, USA
Table 3
Titers for HEV in samples from laboratory rats, Los Angeles, California, USA*
Sample type and source | log10 ID50 | log10 RT-PCR50 |
---|---|---|
Feces | ||
Rat B76† | <1 | 3.4 |
Rat B84† |
<1 |
3.4 |
Intestinal contents: Rat B182 | ||
Small intestine | <3 | 4.9 |
Cecum | <3 | 5.4 |
Colon |
<3 |
4.9 |
Serum | ||
Rat B182 | ND | 3.7 |
Rat B300 | ND | <2.2 |
Rat B350 |
3.7 |
4.7 |
Liver | ||
Rat B182 | 4.7 | 7.2 |
Rat B300 | 4.2 | 5.7 |
Rat B350 | 6.2 | 7.7 |
*Values are per milliliter or per gram. HEV, hepatitis E virus; ID50, 50% infectious dose; RT-PCR50, 50% reverse transcription PCR titer; ND, not determined.
†Serum from wild rats was injected into laboratory rats B76 and B84. Samples from these 2 rats were serially passaged into other laboratory rats (wild rat → rat B76 → rat B300; wild rat → rat B84 → rat B182 → rat B350).
1Current affiliation: Embassy of France, Beijing, People’s Republic of China.
2Current affiliation: National Institutes of Health, Frederick, Maryland, USA.