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Volume 17, Number 12—December 2011
Research

A Pilot Study of Host Genetic Variants Associated with Influenza-associated Deaths among Children and Young Adults1

Jill M. FerdinandsComments to Author , Amy M. Denison, Nicole F. Dowling, Heather A. Jost, Marta L. Gwinn, Lindy Liu, Sherif R. Zaki, and David K. Shay
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table 3

Associations between MBL2 haplotypes and invasive bacterial co-infection in fatal influenza in children and young adults, United States, 1998–99 through 2007–08 influenza seasons*

Outcome Estimated odds ratio (95% CI)
Low producing
MBL2 haplotype† Intermediate or high producing
MBL2 haplotype‡ p value
MRSA, n = 8 7.1 (1.6–32.1) Referent 0.02
Staphylococcus aureus, n = 13 3.0 (0.8–11.2) Referent 0.11
Bacterial co-infection, n = 22 2.7 (0.9–8.6) Referent 0.10

*MBL2, mannose-binding lectin gene; MRSA, methicillin-resistant Staphylococcus aureus.
†includes MBL2 haplotypes O/O and XA/O.
‡includes MBL2 intermediate producer haplotypes XA/XA and YA/O and high producer haplotypes XA/YA and YA/YA.

Main Article

1Portions of this study were presented at the Options for the Control of Influenza VII meeting, September 3–7, 2010, Hong Kong.

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Page updated: December 01, 2011
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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