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Volume 17, Number 12—December 2011


A Pilot Study of Host Genetic Variants Associated with Influenza-associated Deaths among Children and Young Adults1

Jill M. FerdinandsComments to Author , Amy M. Denison, Nicole F. Dowling, Heather A. Jost, Marta L. Gwinn, Lindy Liu, Sherif R. Zaki, and David K. Shay
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table 3

Associations between MBL2 haplotypes and invasive bacterial co-infection in fatal influenza in children and young adults, United States, 1998–99 through 2007–08 influenza seasons*

Outcome Estimated odds ratio (95% CI)
Low producing
MBL2 haplotype† Intermediate or high producing
MBL2 haplotype‡ p value
MRSA, n = 8 7.1 (1.6–32.1) Referent 0.02
Staphylococcus aureus, n = 13 3.0 (0.8–11.2) Referent 0.11
Bacterial co-infection, n = 22 2.7 (0.9–8.6) Referent 0.10

*MBL2, mannose-binding lectin gene; MRSA, methicillin-resistant Staphylococcus aureus.
†includes MBL2 haplotypes O/O and XA/O.
‡includes MBL2 intermediate producer haplotypes XA/XA and YA/O and high producer haplotypes XA/YA and YA/YA.

Main Article

1Portions of this study were presented at the Options for the Control of Influenza VII meeting, September 3–7, 2010, Hong Kong.