Volume 17, Number 3—March 2011
Letter
Fluoroquinolone-Resistant Mycobacterium tuberculosis, Pakistan, 2005–2009
Kauser Jabeen
, Sadia Shakoor, Shazia Chishti, Afsheen Ayaz, and Rumina Hasan
, Sadia Shakoor, Shazia Chishti, Afsheen Ayaz, and Rumina Hasan
Table
Resistance patterns and fluoroquinolone resistance rates of Mycobacterium tuberculosis isolates from the Aga Khan University Hospital laboratory, Karachi, Pakistan, 2005–2009*
| Year and isolates |
Sensitive† |
Multidrug resistant |
Extensively drug resistant |
Other resistance patterns‡ |
Total |
|---|---|---|---|---|---|
| 2005 | |||||
| Total | 773 | 643 | 5 | 361 | 1,782 |
| Fluoroquinolone resistant |
NT |
112 (17.41) |
5 (100) |
6 (1.66) |
NA |
| 2006 | |||||
| Total | 949 | 728 | 11 | 195 | 1,883 |
| Fluoroquinolone resistant |
NT |
128 (17.58) |
11 (100) |
7 (3.58) |
NA |
| 2007 | |||||
| Total | 1,054 | 782 | 17 | 158 | 2,011 |
| Fluoroquinolone resistant |
NT |
163 (20.84) |
17 (100) |
8 (5.06) |
NA |
| 2008 | |||||
| Total | 1,305 | 991 | 32 | 256 | 2,584 |
| Fluoroquinolone resistant |
NT |
351 (35.41) |
32 (100) |
17 (6.64) |
NA |
| 2009 | |||||
| Total | 1,560 | 1,181 | 53 | 209 | 3,003 |
| Fluoroquinolone resistant |
48 (3.07) |
507 (42.92) |
53 (100) |
23 (11) |
631 (21.01) |
| p value§ |
NA |
<0.001 |
NA |
<0.001 |
NA |
| Total | 5,641 | 4,325 | 118 | 1,179 | 11,263 |
*Values are no. (%) isolates in that category, except p values. NT, not tested; NA, not applicable.
†To isoniazid, rifampin, pyrazinamide, and ethambutol.
‡Other resistance patterns include isoniazid-monoresistant and polydrug-resistant isolates.
§χ2 trend analysis.
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