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Volume 17, Number 5—May 2011
Letter

Quinine-Resistant Malaria in Traveler Returning from French Guiana, 2010

Lionel Bertaux, Philippe Kraemer, Nicolas Taudon, Aurélie Trignol, Maryse Martelloni, Redouan Saidi, Daniel Parzy, Bruno PradinesComments to Author , and Fabrice Simon
Author affiliations: Author affiliations: Institut de Recherche Biomédicale des Armées, Marseille, France (L. Bertaux, N. Taudon, M. Martelloni, D. Parzy, B. Pradines); Laveran Military Teaching Hospital, Marseille (P. Kraemer, A. Trignol, R. Saidi, F. Simon)

Main Article

Table

In vitro susceptibility to standard antimalarial drugs of a fresh isolate of Plasmodium falciparum and after culture adaptation in comparison with P. falciparum 3D7 clone tested with the same plate batches*

Antimalarial drug

Fresh isolate IC50, nmol/L

Cultured isolate IC50, nmol/L, mean ± SD†

3D7 clone IC50, nmol/L, mean ± SD

IC50, isolate:3D7

Resistance cutoff value, nmol/L

Quinine

1,019

1,087 ± 145

171 ± 26

6.0:6.4

>800

Chloroquine

427

492 ± 39

13.9 ± 2.2

30.7:35.4

>100

Monodesethylamodiaquine

157

157 ± 27

16.3 ± 3.5

9.6:9.6

>80

Mefloquine

16.4

14.9 ± 2.2

53.4 ± 5.2

0.31:0.28

>30

Lumefantrine

8.9

9.0 ± 3.0

46.0 ± 6.0

0.19:0.20

>150

Pyronaridine

45.2

37.8 ± 8.4

18.3 ± 1.6

2.5:2.1

ND

Piperaquine

80.4

99.5 ± 11.7

56.3 ± 5.4

1.4:1.8

ND

Dihydroartemisinin

2.18

2.46 ± 0.28

2.58 ± 0.13

0.84:0.95

>10.5

Artesunate

1.86

1.68 ± 0.28

2.27 ± 1.15

0.82:0.74

>10.5

Atovaquone

6.5

5.2 ± 0.8

4.2 ± 0.7

1.5:1.2

>490

Doxycycline

11,600

12,600 ± 1,700

12,600 ± 1,000

0.92:1.0

>35,000

*Isolate was obtained from a man who returned to France from French Guiana in June 2010. IC50, 50% inhibitory concentration; ND, not determined.
†Mean IC50 and standard deviation of 3 different tests on the isolate after culture adaptation.

Main Article

Page created: August 09, 2011
Page updated: August 09, 2011
Page reviewed: August 09, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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