Volume 17, Number 5—May 2011
Dispatch
Chikungunya Virus, Southeastern France
Marc Grandadam
, Valérie Caro, Sébastien Plumet, Jean-Michel Thiberge, Yvan Souarès, Anna-Bella Failloux, Hugues J. Tolou, Michel Budelot, Didier Cosserat, Isabelle Leparc-Goffart, and Philippe Desprès
, Valérie Caro, Sébastien Plumet, Jean-Michel Thiberge, Yvan Souarès, Anna-Bella Failloux, Hugues J. Tolou, Michel Budelot, Didier Cosserat, Isabelle Leparc-Goffart, and Philippe Desprès
Table
Relevant amino acid substitutions identified between France/2010 CHIKV isolates (autochthonous and imported cases) versus a selection of CHIKV strains*
| Strain |
Country |
Year |
Protein position | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| E2-60 |
E2-162 |
E2-211 |
E2-264† |
E1-211 |
E1-226 |
E1-269 |
E1-284 |
|||
| France/2010/1630/human/ imported (a) | France (India) | 2010 | D | A | T | A | E | A | V | E |
| France/2010/1909/human/ autochthonous (a) | France | 2010 | D | A | T | A | E | A | V | E |
| 22833 (a) | Côte d'Ivoire | 1990 | D | A | I | V | K | A | M | D |
| CHIK31 (a) | India | 2006 | D | A | T | V | K | A | V | E |
| 05209 (a) | Seychelles | 2005 | D | A | T | V | K | A | V | E |
| 0561 (a) | Réunion | 2005 | D | A | T | V | K | A | V | E |
| 0649 (a) | Réunion | 2005 | D | A | T | V | K | V | V | E |
| DHS4263-Calif-AB (a) | California (India) | 2006 | D | A | T | V | K | A | V | E |
| IND-GJ53 (a) | India | 2006 | D | A | T | V | K | A | V | E |
| IND-KR52 (a) | India | 2007 | D | A | T | V | K | V | V | E |
| ITA07-RA1 (a) | Italy | 2007 | D | A | T | V | K | V | V | E |
| KEN-Lamu-Oct04-KPA15 (a) | Kenya | 2004 | D | A | T | V | K | A | V | E |
| KEN-Mom-Jul04-33 (a) | Kenya | 2004 | D | A | T | V | K | A | V | E |
| S27 (a) | Tanzania | 1952 | D | A | I | V | K | A | M | D |
| SGEHICHD13508 (a) | Singapore | 2008 | D | A | T | V | K | A | V | E |
| CHIK/Pt11201/SIN/2009 (a) | France (Singapore) | 2009 | D | A | T | V | K | V | V | E |
| SL-CK1 (a) | Sri Lanka | 2007 | D | A | T | V | K | A | V | E |
| SL-CR 3 (a) | Sri Lanka | 2007 | D | A | T | V | K | A | V | E |
| Nagpur (India) 653496 (b) | India | 2003 | D | A | T | V | E | A | M | D |
| CHIK/Pt11352/INDO/2009 (b) | France (Indonesia) | 2009 | D | A | T | V | E | A | M | D |
| s37997 (c) | Senegal | 1983 | D | A | T | V | K | A | V | D |
*Molecular signatures were based on the analysis of complete amino acid sequence E2-6K-E1 (923 aa). The numbering of amino acid positions refers to the African isolate S27 (GenBank access no. AF369024). Residues in boldface indicate critical aa changes. Letters in parentheses after strain names refer to East/Central/South Africa (a), Asia (b) and West Africa (c) phylogroups. Country names in parentheses identify source of imported case. CHIKV, chikungunya virus.
†The amino acid substitution was unique to France/2010 CHIKV isolates.
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