Volume 17, Number 9—September 2011
Research
Role of Chlamydia trachomatis in Miscarriage
David Baud, Genevieve Goy, Katia Jaton, Maria-Chiara Osterheld, Serafin Blumer, Nicole Borel, Yvan Vial, Patrick Hohlfeld, Andreas Pospischil, and Gilbert Greub
Table 2
Clinical history and serologic, PCR, and IHC results of 8 women with samples positive for Chlamydia trachomatis by real-time PCR, University Hospital of Lausanne, Lausanne, Switzerland, November 2006–June 2009*
| Study group, patient no. |
No. pregnancies |
Parity |
Pregnancy, wk |
C. trachomatis PCR |
Placental histology |
||||
| IgG |
IgA |
Placenta PCR |
Vagina PCR |
IHC |
|||||
| Miscarriage group | |||||||||
| 235 | 2 | 0 | 8 | + | – | + | + | + | Lymphocytes in chorion, acute endometritis |
| 355 | 1 | 0 | 7 | + | – | + | + | – | Polymorphonuclear cells in decidua |
| 518 | 2 | 0 | 6 | + | – | + | + | + | Subchorial fibrin, lymphocytes in decidua |
| 564 | 5 | 2 | 12 | + | + | + | + | + | Lymphocytes in decidua |
| 568 | 2 | 1 | 6 | - | – | + | – | – | Lymphocytes in decidua, hemorrhagic necrosis |
| 460 |
1 |
0 |
11 |
+ |
+ |
– |
+ |
+ |
Presence of eosinophils |
| Control group | |||||||||
| 35 | 2† | 1 | 37 | + | – | + | + | – | Histiocytes, rare calcifications |
| 390 | 1 | 1 | 40 | + | – | + | + | + | Chronic deciduitis |
*Ig, immunoglobulin; IHC, Immunohistochemical analysis; +, positive; –, negative.
†One previous termination of pregnancy.
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