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Volume 18, Number 1—January 2012


Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model

Nadine Mestre-FrancésComments to Author , Simon Nicot, Sylvie Rouland, Anne-Gaëlle Biacabe, Isabelle Quadrio, Armand Perret-Liaudet, Thierry Baron, and Jean-Michel Verdier
Author affiliations: Institut National de la Santé et de la Recherche Médicale (INSERM) U710, Montpellier, France (N. Mestre-Francés, S. Rouland, J.-M. Verdier); Université Montpellier 2, Montpellier (N. Mestre-Francés, S. Rouland, J.-M. Verdier); École Pratique des Hautes Etudes, Paris, France (N. Mestre-Francés, S. Rouland, J.-M. Verdier); Agence Nationale de Sécurité Sanitaire, Lyon, France (S. Nicot, A.-G. Biacabe, T. Baron); Hopitaux Civils de Lyon, Lyon, France (I. Quadrio, A. Perret-Liaudet); Université Lyon 1, Lyon (I. Quadrio, A. Perret-Liaudet); INSERM U1028, Lyon (I. Quadrio, A. Perret-Liaudet); Centre National de la Recherche Scientifique, Lyon (I. Quadrio, A. Perret-Liaudet)

Main Article


Experimental transmission of cattle-derived L-BSE agent to 12 mouse lemurs, by 2 routes of inoculation*

Inoculation route L-BSE dose, mg Inoculated animals
No. inoculated (no. alive) Age at inoculation Survival after inoculation, mo Positive for PrPd †
Intracerebral 5 4 1 y 19; 19.5; 22; 22 4/4
Oral 50 3 (1‡) 2 mo or 2 y 18‡; 32 2/2
Oral 5 5 (2‡) 2 mo or 2 y 27; 33; 34 2/3

*L-BSE, L-type bovine spongiform encephalopathy source; PrPd, disease-associated prion protein. Source of L-BSE, 02–2528.
†Results obtained by Western blot analysis and/or paraffin-embedded tissue-blot analysis and/or immunohistochemical analysis.
‡Animals were inoculated at 2 y of age.

Main Article