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Volume 18, Number 12—December 2012
Dispatch

Differentiation of Prions from L-type BSE versus Sporadic Creutzfeldt-Jakob Disease

Simon Nicot, Anna Bencsik, Eric Morignat, Nadine Mestre-Francés, Armand Perret-Liaudet, and Thierry BaronComments to Author 
Author affiliations: Author affiliations: Agence Nationale de Sécurité Sanitaire (Anses), Lyon, France (S. Nicot, A. Bencsik, E. Morignat, T. Baron); INSERM U710, Montpellier, France; Université Montpellier 2, Montpellier; École Pratique des Hautes Études, Paris, France (N. Mestre-Francés); Hôpitaux Civils de Lyon, Université Lyon 1, INSERM U1028, and Centre National de la Recherche Scientifique, Lyon (A. Perret-Liaudet)

Main Article

Table

Comparison of transmission of sCJD and L-BSE in hamsters and mice

Hosts and inoculum Passage Mean survival time, dpi ± SD No. brain PrPd positive/no. tested No. spleen PrPres positive/no. tested
Syrian golden hamsters

sCJD MM2-cortical

1 833 ± 33 0/4 0/4

L-BSE lemur

1 529 ± 177 5/5 1/4

L-BSE cattle (02-2528)

1 622 ± 64† 4/5† 0/5
TgOvPrP4 mice

sCJD MM2-cortical

1 639 ± 49 3/4 0/4

L-BSE lemur

1 509 ± 97 7/7 7/7

L-BSE cattle (02-2528)

1 627 ± 74‡ 9/10‡ 0/5§

L-BSE cattle (08-0074)

1 497 ± 49 6/8 0/9

sCJD MM2-cortical

2 111 ± 25 12/12 12/12

L-BSE lemur

2 194 ± 7 12/12 12/12

L-BSE cattle (02-2528)

2 202 ± 26‡ 9/9‡ 3/5

L-BSE cattle (08-0074)

2 186 ± 37 12/12 9/11

*Isolate identification numbers are shown in parentheses. sCJD, sporadic Creutzfeldt-Jakob disease; L-BSE, L-type bovine spongiform encephalopathy; TgOvPrP4, ovine prion protein–transgenic; dpi, days postinoculation; PrPd, disease-associated prion protein; PrPres, protease-resistant prion protein.
†Data from (7).
‡Data from (8).
§Data from (10).

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References
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Page created: November 08, 2012
Page updated: November 08, 2012
Page reviewed: November 08, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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