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Volume 18, Number 12—December 2012
Dispatch

Differentiation of Prions from L-type BSE versus Sporadic Creutzfeldt-Jakob Disease

Simon Nicot, Anna Bencsik, Eric Morignat, Nadine Mestre-Francés, Armand Perret-Liaudet, and Thierry BaronComments to Author 
Author affiliations: Author affiliations: Agence Nationale de Sécurité Sanitaire (Anses), Lyon, France (S. Nicot, A. Bencsik, E. Morignat, T. Baron); INSERM U710, Montpellier, France; Université Montpellier 2, Montpellier; École Pratique des Hautes Études, Paris, France (N. Mestre-Francés); Hôpitaux Civils de Lyon, Université Lyon 1, INSERM U1028, and Centre National de la Recherche Scientifique, Lyon (A. Perret-Liaudet)

Main Article

Table

Comparison of transmission of sCJD and L-BSE in hamsters and mice

Hosts and inoculum Passage Mean survival time, dpi ± SD No. brain PrPd positive/no. tested No. spleen PrPres positive/no. tested
Syrian golden hamsters

sCJD MM2-cortical

 1 833 ± 33 0/4 0/4

L-BSE lemur

 1 529 ± 177 5/5 1/4

L-BSE cattle (02-2528)

 1 622 ± 64† 4/5† 0/5
TgOvPrP4 mice

sCJD MM2-cortical

 1 639 ± 49 3/4 0/4

L-BSE lemur

 1 509 ± 97 7/7 7/7

L-BSE cattle (02-2528)

 1 627 ± 74‡ 9/10‡ 0/5§

L-BSE cattle (08-0074)

 1 497 ± 49 6/8 0/9

sCJD MM2-cortical

 2 111 ± 25 12/12 12/12

L-BSE lemur

 2 194 ± 7 12/12 12/12

L-BSE cattle (02-2528)

 2 202 ± 26‡ 9/9‡ 3/5

L-BSE cattle (08-0074)

 2 186 ± 37 12/12 9/11

*Isolate identification numbers are shown in parentheses. sCJD, sporadic Creutzfeldt-Jakob disease; L-BSE, L-type bovine spongiform encephalopathy; TgOvPrP4, ovine prion protein–transgenic; dpi, days postinoculation; PrPd, disease-associated prion protein; PrPres, protease-resistant prion protein.
†Data from (7).
‡Data from (8).
§Data from (10).

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References
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Page updated: November 08, 2012
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