Volume 18, Number 12—December 2012
Dispatch
Differentiation of Prions from L-type BSE versus Sporadic Creutzfeldt-Jakob Disease
Table
Hosts and inoculum | Passage | Mean survival time, dpi ± SD | No. brain PrPd positive/no. tested | No. spleen PrPres positive/no. tested |
---|---|---|---|---|
Syrian golden hamsters | ||||
sCJD MM2-cortical |
1 | 833 ± 33 | 0/4 | 0/4 |
L-BSE lemur |
1 | 529 ± 177 | 5/5 | 1/4 |
L-BSE cattle (02-2528) |
1 | 622 ± 64† | 4/5† | 0/5 |
TgOvPrP4 mice | ||||
sCJD MM2-cortical |
1 | 639 ± 49 | 3/4 | 0/4 |
L-BSE lemur |
1 | 509 ± 97 | 7/7 | 7/7 |
L-BSE cattle (02-2528) |
1 | 627 ± 74‡ | 9/10‡ | 0/5§ |
L-BSE cattle (08-0074) |
1 | 497 ± 49 | 6/8 | 0/9 |
sCJD MM2-cortical |
2 | 111 ± 25 | 12/12 | 12/12 |
L-BSE lemur |
2 | 194 ± 7 | 12/12 | 12/12 |
L-BSE cattle (02-2528) |
2 | 202 ± 26‡ | 9/9‡ | 3/5 |
L-BSE cattle (08-0074) |
2 | 186 ± 37 | 12/12 | 9/11 |
*Isolate identification numbers are shown in parentheses. sCJD, sporadic Creutzfeldt-Jakob disease; L-BSE, L-type bovine spongiform encephalopathy; TgOvPrP4, ovine prion protein–transgenic; dpi, days postinoculation; PrPd, disease-associated prion protein; PrPres, protease-resistant prion protein.
†Data from (7).
‡Data from (8).
§Data from (10).
References
- Comoy EE, Casalone C, Lescoutra-Etchegaray N, Zanusso G, Freire S, Marce D, Atypical BSE (BASE) transmitted from asymptomatic aging cattle to a primate. PLoS ONE. 2008;3:e3017. DOIPubMedGoogle Scholar
- Ono F, Tase N, Kurosawa A, Hiyaoka A, Ohyama A, Tezuka Y, Atypical L-type bovine spongiform encephalopathy (L-BSE) transmission to cynomolgus macaques, a non-human primate. Jpn J Infect Dis. 2011;64:81–4 .PubMedGoogle Scholar
- Mestre-Francés N, Nicot S, Rouland S, Biacabe AG, Quadrio I, Perret-Liaudet A, Oral transmission of L-type bovine spongiform encephalopathy in primate model. Emerg Infect Dis. 2012;18:142–5. DOIPubMedGoogle Scholar
- Kong Q, Zheng M, Casalone C, Qing L, Huang S, Chakraborty B, Evaluation of the human transmission risk of an atypical bovine spongiform encephalopathy prion strain. J Virol. 2008;82:3697–701. DOIPubMedGoogle Scholar
- Béringue V, Herzog L, Reine F, Le Dur A, Casalone C, Vilotte JL, Transmission of atypical bovine prions to mice transgenic for human prion protein. Emerg Infect Dis. 2008;14:1898–901. DOIPubMedGoogle Scholar
- Casalone C, Zanusso G, Acutis P, Ferrari S, Capucci L, Tagliavini F, Identification of a second bovine amyloidotic spongiform encephalopathy: molecular similarities with sporadic Creutzfeldt-Jakob disease. Proc Natl Acad Sci U S A. 2004;101:3065–70. DOIPubMedGoogle Scholar
- Nicot S, Baron T. Strain-specific barriers against bovine prions in hamsters. J Virol. 2011;85:1906–8. DOIPubMedGoogle Scholar
- Baron T, Bencsik A, Biacabe AG, Morignat E, Bessen RA. Phenotypic similarity of transmissible mink encephalopathy in cattle and L-type bovine spongiform encephalopathy in a mouse model. Emerg Infect Dis. 2007;13:1887–94. DOIPubMedGoogle Scholar
- Parchi P, Giese A, Capellari S, Brown P, Schulz-Schaeffer W, Windl O, Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects. Ann Neurol. 1999;46:224–33. DOIPubMedGoogle Scholar
- Baron T, Bencsik A, Morignat E. Prions of ruminants show distinct splenotropisms in an ovine transgenic mouse model. PLoS ONE. 2010;5:e10310. DOIPubMedGoogle Scholar
- Shu Y, Masujin K, Okada H, Iwamaru Y, Imamura M, Matsuura Y, Characterization of Syrian hamster adapted prions derived from L-type and C-type bovine spongiform encephalopathies. Prion. 2011;5:103–8. DOIPubMedGoogle Scholar
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