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Volume 18, Number 2—February 2012


Association of Human Bocavirus 1 Infection with Respiratory Disease in Childhood Follow-up Study, Finland

Mira Meriluoto, Lea Hedman, Laura Tanner, Ville Simell, Marjaana Mäkinen, Satu Simell, Juha Mykkänen, Jan Korpelainen, Olli Ruuskanen, Jorma Ilonen, Mikael Knip, Olli Simell, Klaus Hedman, and Maria Söderlund-VenermoComments to Author 
Author affiliations: University of Helsinki, Helsinki, Finland (M. Meriluoto, L. Hedman, M. Knip, K. Hedman, M. Söderlund-Venermo); Haartman Institute, Helsinki (M. Meriluoto, L. Hedman, K. Hedman, M. Söderlund-Venermo); Helsinki University Central Hospital, Helsinki (L. Hedman, M. Knip, K. Hedman); University of Turku, Turku, Finland (L. Tanner, V. Simell, M. Mäkinen, S. Simell, J. Mykkänen, J. Korpelainen, O. Ruuskanen, J. Ilonen, O. Simell); University of Eastern Finland, Kuopio, Finland (J. Ilonen); Tampere University Hospital, Tampere, Finland (M. Knip); Folkhälsan Research Center, Helsinki (M. Knip)

Main Article

Table 1

Human bocavirus IgG results from 109 constitutionally healthy children, Finland

Result* No. (%) Age, y
Mean Median Range
Seroconversion 102 (94) 2.30 2.08 0.31–6.00
Secondary response† 38 (35) 4.79 4.77 0.73–9.79
Reconversion 7 (6) 6.29 7.07 1.59–8.15

*Maternal antibodies, i.e., low-level (vanishing) IgG, were detected in 35/88 children from whom serum was taken ≤6 mo. of age. Seven children were IgG positive from birth, and their maternal antibodies were not seen to disappear before induction of their own immunity. For 73, the IgG level remained high; for 26, the IgG level decreased with time; and 10 underwent IgG reversion.
>4-fold increase in, or reconversion of, high avidity IgG (2 children had 2 and 2 other children had 3 secondary immune responses).

Main Article