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Volume 18, Number 2—February 2012


Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus Infections, United States, 2010–11

Aaron D. Storms, Larisa V. Gubareva, Su Su, John T. Wheeling, Margaret Okomo-Adhiambo, Chao-Yang Pan, Erik Reisdorf, Kirsten St. George, Robert Myers, Jason T. Wotton, Sara Robinson, Brandon Leader, Martha Thompson, Marjorie Shannon, Alexander Klimov, Alicia M. FryComments to Author , and for the US Antiviral Resistance Surveillance Working Group
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (A.D. Storms, L.V. Gubareva, S. Su, J.T. Wheeling, M. Okomo-Adhiambo, A. Klimov, A.M. Fry); California Department of Public Health, Sacramento, California, USA (C.-Y. Pan); Wisconsin State Laboratory of Hygiene, Madison, Wisconsin, USA (E. Reisdorf); New York State Department of Health, Albany, New York, USA (K. St. George); Maryland Department of Health and Mental Hygiene, Baltimore, Maryland, USA (R. Myers); Minnesota Department of Health, Saint Paul, Minnesota, USA (J.T. Wotton); Maine Department of Health and Human Services, Augusta, Maine, USA (S. Robinson); Washington State Department of Health, Shoreline, Washington, USA (B. Leader); Texas Department of State Health Services, Austin, Texas, USA (M. Thompson); Delaware Health and Social Services, New Castle, Delaware, USA (M. Shannon)

Main Article

Table 2

Temporal trends of oseltamivir-resistant pandemic (H1N1) 2009 viruses and history of patient exposure to oseltamivir, by month, United States, October 1, 2010–July 31, 2011

Year and month of specimen collection No. specimens tested No. (%) oseltamivir-resistant specimens No. (%) patients with oseltamivir-resistant virus but no oseltamivir exposure
2010 Oct 9 0 0
2010 Nov 17 0 0
2010 Dec 172 1 (0.6) 0
2011 Jan 1,074 6 (0.6) 4 (66.7)
2011 Feb 1,475 18 (1.2) 15 (83.3)
2011 Mar 801 9 (1.1) 6 (66.7)
2011 Apr 95 1 (1.0) 1 (100.0)
2011 May 8 0 0
2011 Jun 0 0 0
2011 Jul 1 0 0
Total 3,652 35 (1.0) 25 (73.5)*

*Oseltamivir exposure known for 34 of 35 patients.

Main Article

1Additional members of the US Antiviral Resistance Surveillance Working Group who contributed data are listed at the end of this article.