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Volume 18, Number 4—April 2012


Cosavirus Infection in Persons with and without Gastroenteritis, Brazil

Andreas Stöcker1, Breno Frederico de Carvalho Dominguez Souza1, Tereza Cristina Medrado Ribeiro1, Eduardo Martins Netto, Luciana Oliveira Araujo, Jefferson Ivan Corrêa, Patrícia Silva Almeida, Angela Peixoto de Mattos, Hugo da Costa Ribeiro, Diana Brasil Pedral-Sampaio, Christian Drosten, and Jan Felix DrexlerComments to Author 
Author affiliations: University of Bonn Medical Centre, Bonn, Germany (A. Stöcker, C. Drosten, J.F. Drexler); Federal University of Bahia, Salvador, Brazil (A. Stocker, B.F.C.D. Souza, T.C.M. Ribeiro, E.M. Netto, L.O. Araujo, J.I. Corrêa, P.S. Almeida, A.P. de Mattos, H.C. Ribeiro Jr, D.B. Pedral Sampaio)

Main Article

Table 1

Clinical cohorts tested for cosavirus, Salvador, Brazil*

Cohort no. Cohort description† Sampling site‡ Sampling time Participant age, mo, mean (SD) No. participants No. (%) RT-PCR positive§ Virus concentration, log10 RNA copies/g feces, mean (SD)¶
1 HIV-infected adults with gastroenteritis Infectious Diseases HIV Outpatient Department 2007 Mar–2010 Mar 487.6 (114.4) 105 1 (1.0) 4.43
2 HIV-infected adults without gastroenteritis 2007 Mar–2010 Mar 533.8 (115.9) 49 0
3 Children with gastroenteritis Department of Pediatrics Metabolic Unit# 2006 Feb–2007 Sep 19.0 (15.6) 359 13 (3.6) 3.40 (0.93)
4 Control children without gastroenteritis Community child-care center** 2008 Dec 29.6 (13.1) 132 65 (49.2) 2.97 (0.97)
5 Control children without gastroenteritis Community child-care center** 2011 Nov–2011 Dec 14.3 (5.5) 62 4 (6.5) 3.41 (0.49)
6 Control children without gastroenteritis University child-care center** 2011 Oct–2011 Nov 18.6 (4.2) 10 0
Total 717 83 (11.6)

*RT-PCR, reverse transcription PCR; –, no virus obtained.
†Gastroenteritis was defined as acute diarrhea with >3 watery stools in the previous 24 h and within 13 d before hospital admission.
‡All hospital units were located within the Hospital Professor Edgard Santos, Federal University of Bahia. All sites were located in Salvador, Bahia, in northeastern Brazil.
§Samples only considered if positive in nested RT-PCR as in (3) and in strain-specific real-time RT-PCR.
¶Measured by strain-specific RT-PCR.
#Reports of diarrhea in the preceding 2 wk served as an exclusion factor.
**Written consent was obtained from adult family members.

Main Article

1These authors contributed equally to this article.