Volume 18, Number 8—August 2012
Research
Population Diversity among Bordetella pertussis Isolates, United States, 1935–2009
Amber J. Schmidtke, Kathryn O. Boney, Stacey W. Martin, Tami H. Skoff, M. Lucia Tondella, and Kathleen M. Tatti
Table
Diversity trends among selected Bordetella pertussis isolates, United States, 1935–2009*
| Study period | Years | Vaccine use | Simpson diversity index, % (95% CI) |
|---|---|---|---|
| 1 | 1935–1945 | Pre-wP | 66.7 (30.4–103.0) |
| 2 | 1946–1969 | Early-wP | 77.8 (59.4–96.2) |
| 3 | 1970–1990 | Late-wP | 94.0 (90.9–97.1) |
| 4 | 1991–1996 | wP/aP transition (4th–5th doses) | 75.7 (65.9–85.5) |
| 5 | 1997–1999 | Early-aP | 66.8 (59.5–74.1) |
| 6 | 2000–2002 | Mid-aP | 70.2 (67.7–81.1) |
| 7 | 2003–2005 | Late-aP | 71.6 (62.4–80.8) |
| 8 | 2006–2009 | Tdap | 69.3 (60.7–77.9) |
*wP, whole cell vaccine; aP, acellular vaccine; Tdap, tetanus-diphtheria-aP.
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