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Volume 19, Number 1—January 2013
CME ACTIVITY - Research

Pneumocystis jirovecii Genotype Associated with Increased Death Rate of HIV-infected Patients with Pneumonia

Meja Rabodonirina, Laetitia Vaillant, Patrick Taffé, Aimable Nahimana, René-Pierre Gillibert, Philippe Vanhems, and Philippe M. HauserComments to Author 
Author affiliations: Author affiliations: Université Claude-Bernard Hôpital de la Croix-Rousse, Lyon, France (M. Rabodonirina); Service d’Hygiène, Epidémiologie et Prévention, Hôpital Edouard Herriot, Lyon (L. Vaillant, R.-P. Gillibert, P. Vanhems); Institut de Veille Sanitaire, Paris, France (L. Vaillant); Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland (P. Taffé, A. Nahimana, P.M. Hauser); Claude Bernard Lyon 1 University, Lyon (P. Vanhems)

Main Article

Table 1

Pneumocystis jiroveci dihydropteroate synthase genotype distribution according to clinical parameters of 112 cases of pneumonia in 110 HIV-positive patients from 5 university hospitals in Lyon, France*

Wild type, n = 75 M2, n = 17 M3, n = 20
Age at PCP diagnosis, y

1–40

 41 10 14 0.62

41–60

 31 7 5

61–80

 3
0
1
Sex

M

 62 14 19 0.38

F

 13
3
1
Diagnosis year

1993

 6 2 0 0.58

1994

 24 3 4

1995

 20 5 6

1996

 25
7
10
CD4 cell count, median cells/μL†

0–50

 42 15 11 0.05

51–100

 17 0 4

>100

 10
0
2
First-line treatment

SMX/TMP

 59 14 15 0.90

Pentamidine or atovaquone

 14 3 5

Others

 2
0
0
SMX/TMP allergy

Yes

 4 0 3 0.27

No

 71
17
17
Corticotherapy at PCP diagnosis

Yes

 18 1 3 0.25

No

 57
16
17
Mechanical ventilation at PCP diagnosis

Yes

 11 0 3 0.26

No

 64
17
17
P. jirovecii SSCP type 1 3 6 1 <0.001

7

 3 0 6

10

 2 1 1

Others

 30 3 3

Co-infected

 37
7
9
Outcome within 1 month

Favorable

 61 16 14 0.39

Death attributed to PCP

 12 1 5

Death not attributed to PCP

 2 0 1

*Data derived from Fisher’s exact test. DHPS, dihydropteroate synthase; M, mutation; SSCP, single-strand conformation polymorphism; PCP, P. jirovecii pneumonia; SMX/TMP, sulfamethoxazole and trimethoprim.
†Data missing for 11 patients.

Main Article

Page created: December 20, 2012
Page updated: December 20, 2012
Page reviewed: December 20, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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