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Volume 19, Number 1—January 2013
CME ACTIVITY - Research

Pneumocystis jirovecii Genotype Associated with Increased Death Rate of HIV-infected Patients with Pneumonia

Meja Rabodonirina, Laetitia Vaillant, Patrick Taffé, Aimable Nahimana, René-Pierre Gillibert, Philippe Vanhems, and Philippe M. HauserComments to Author 
Author affiliations: Author affiliations: Université Claude-Bernard Hôpital de la Croix-Rousse, Lyon, France (M. Rabodonirina); Service d’Hygiène, Epidémiologie et Prévention, Hôpital Edouard Herriot, Lyon (L. Vaillant, R.-P. Gillibert, P. Vanhems); Institut de Veille Sanitaire, Paris, France (L. Vaillant); Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland (P. Taffé, A. Nahimana, P.M. Hauser); Claude Bernard Lyon 1 University, Lyon (P. Vanhems)

Main Article

Table 2

Pneumocystis jiroveci SSCP genotype distribution according to clinical parameters of 112 cases of pneumonia in 110 HIV-positive patients from 5 university hospitals in Lyon, France*

1, n = 10 7, n = 9 10, n = 4 Others, n = 36 Co-infected, n = 53
Age at PCP diagnosis, y

1–40

 8 5 2 22 28 0.89

41–60

 2 4 2 13 22

61–80

 0
0
0
1
3
Sex

M

 3 1 1 6 6 0.44

F

 7
8
3
30
47
Diagnosis year

1993

 1 0 0 2 5 0.90

1994

 3 2 2 8 16

1995

 2 2 1 9 17

1996

 4
5
1
17
15
CD4 cell count, median cells/μL†

0–50

 7 5 3 23 30 0.87

51–100

 0 2 1 6 12

>100

 1
1
0
5
5
First-line treatment

SMX/TMP

 7 3 3 26 49 0.001

Pentamidine or atovaquone

 2 6 1 9 4

Others

 1
0
0
1
0
SMX/TMP allergy

Yes

 0 2 0 3 2 0.27

No

 10
7
4
33
51
Corticotherapy at PCP diagnosis

Yes

 0 4 0 7 11 0.17

No

 10
5
4
29
42
Mechanical ventilation at PCP diagnosis

Yes

 0 2 0 2 10 0.19

No

 10
7
4
34
43
Outcome within 1 month

Favorable

 9 5 4 28 45 0.44

Death attributed to PCP

 1 4 0 6 7

Death not attributed to PCP

 0 0 0 2 1

*Data derived from Fisher’s exact test. SSCP, single-strand conformation polymorphism; PCP, P. jirovecii pneumonia; SMX/TMP, sulfamethoxazole and trimethoprim.
†Data missing for 11 patients.

Main Article

Page created: December 20, 2012
Page updated: December 20, 2012
Page reviewed: December 20, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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