Volume 19, Number 1—January 2013
CME ACTIVITY - Research
Pneumocystis jirovecii Genotype Associated with Increased Death Rate of HIV-infected Patients with Pneumonia
Meja Rabodonirina, Laetitia Vaillant, Patrick Taffé, Aimable Nahimana, René-Pierre Gillibert, Philippe Vanhems, and Philippe M. Hauser
Table 2
Pneumocystis jiroveci SSCP genotype distribution according to clinical parameters of 112 cases of pneumonia in 110 HIV-positive patients from 5 university hospitals in Lyon, France*
| 1, n = 10 | 7, n = 9 | 10, n = 4 | Others, n = 36 | Co-infected, n = 53 | ||
|---|---|---|---|---|---|---|
| Age at PCP diagnosis, y | ||||||
|
1–40 |
8 | 5 | 2 | 22 | 28 | 0.89 |
|
41–60 |
2 | 4 | 2 | 13 | 22 | |
|
61–80 |
0
|
0
|
0
|
1
|
3
|
|
| Sex | ||||||
|
M |
3 | 1 | 1 | 6 | 6 | 0.44 |
|
F |
7
|
8
|
3
|
30
|
47
|
|
| Diagnosis year | ||||||
|
1993 |
1 | 0 | 0 | 2 | 5 | 0.90 |
|
1994 |
3 | 2 | 2 | 8 | 16 | |
|
1995 |
2 | 2 | 1 | 9 | 17 | |
|
1996 |
4
|
5
|
1
|
17
|
15
|
|
| CD4 cell count, median cells/μL† | ||||||
|
0–50 |
7 | 5 | 3 | 23 | 30 | 0.87 |
|
51–100 |
0 | 2 | 1 | 6 | 12 | |
|
>100 |
1
|
1
|
0
|
5
|
5
|
|
| First-line treatment | ||||||
|
SMX/TMP |
7 | 3 | 3 | 26 | 49 | 0.001 |
|
Pentamidine or atovaquone |
2 | 6 | 1 | 9 | 4 | |
|
Others |
1
|
0
|
0
|
1
|
0
|
|
| SMX/TMP allergy | ||||||
|
Yes |
0 | 2 | 0 | 3 | 2 | 0.27 |
|
No |
10
|
7
|
4
|
33
|
51
|
|
| Corticotherapy at PCP diagnosis | ||||||
|
Yes |
0 | 4 | 0 | 7 | 11 | 0.17 |
|
No |
10
|
5
|
4
|
29
|
42
|
|
| Mechanical ventilation at PCP diagnosis | ||||||
|
Yes |
0 | 2 | 0 | 2 | 10 | 0.19 |
|
No |
10
|
7
|
4
|
34
|
43
|
|
| Outcome within 1 month | ||||||
|
Favorable |
9 | 5 | 4 | 28 | 45 | 0.44 |
|
Death attributed to PCP |
1 | 4 | 0 | 6 | 7 | |
|
Death not attributed to PCP |
0 | 0 | 0 | 2 | 1 |
*Data derived from Fisher’s exact test. SSCP, single-strand conformation polymorphism; PCP, P. jirovecii pneumonia; SMX/TMP, sulfamethoxazole and trimethoprim.
†Data missing for 11 patients.
Page created: December 20, 2012
Page updated: December 20, 2012
Page reviewed: December 20, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.