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Volume 19, Number 10—October 2013
Dispatch

Safe Pseudovirus-based Assay for Neutralization Antibodies against Influenza A(H7N9) Virus

Chao Qiu1, Yang Huang1, Anli Zhang1, Di Tian1, Yanmin Wan1, Xiaoling Zhang, Wanju Zhang, Zhiyong Zhang, Zhenghong Yuan, Yunwen Hu, Xiaoyan Zhang, and Jianqing XuComments to Author 
Author affiliations: Shanghai Public Health Clinical Center, Shanghai, China (C. Qiu, A. Zhang, D. Tian, Y. Wan, Xiaoling Zhang, W. Zhang, Z. Zhang, Z. Yuan, Y. Hu, Xiaoyan Zhang, J. Xu); Fudan University, Shanghai (C. Qiu, Y. Huang, A. Zhang, Z. Yuan, Xiaoyan Zhang, J. Xu); Chinese Center for Disease Control and Prevention, Beijing, China (Xiaoyan Zhang, J. Xu)

Main Article

Table

Comparison of HI and pseudovirus-based neutralization assay results for influenza A(H7N9) virus*

HI titer†
 Pseudovirus IC50 titer
>40
 <40‡
 >20§
 <20§
+ 12 2 13 1
– 0 50 4 46

*Values are no. samples. HI, hemagglutination inhibition; IC50, 50% inhibitory concentration.
†+ HI titer is >40; – HI titer is <40.
‡κ = 0.904; McNemar test, p = 0.5.
§κ = 0.788; McNemar test, p = 0.375.

Main Article

1These authors contributed equally to this article.

Page created: September 16, 2013
Page updated: September 16, 2013
Page reviewed: September 16, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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