Safe Pseudovirus-based Assay for Neutralization Antibodies against Influenza A(H7N9) Virus
, Yang Huang1
, Anli Zhang1
, Di Tian1
, Yanmin Wan1
, Xiaoling Zhang, Wanju Zhang, Zhiyong Zhang, Zhenghong Yuan, Yunwen Hu, Xiaoyan Zhang, and Jianqing Xu
Author affiliations: Shanghai Public Health Clinical Center, Shanghai, China (C. Qiu, A. Zhang, D. Tian, Y. Wan, Xiaoling Zhang, W. Zhang, Z. Zhang, Z. Yuan, Y. Hu, Xiaoyan Zhang, J. Xu); Fudan University, Shanghai (C. Qiu, Y. Huang, A. Zhang, Z. Yuan, Xiaoyan Zhang, J. Xu); Chinese Center for Disease Control and Prevention, Beijing, China (Xiaoyan Zhang, J. Xu)
Figure. . Correlation between conventional hemagluttination (HI) titer and 50% inhibitory concentration (IC50) titer of pseudovirus-based assay for diagnosing influenza A(H7N9) virus infection. Correlation between the IC50 titer of the pseudovirus-based neutralization assay and the titer of conventional HI assay, tested with 14 serum samples collected >10 days after symptom onset from patients with real-time RT-PCR–confirmed 2013 influenza A(H7N9) infection (○) and 50 control samples (△, Spearman r = 0.88, p<0.0001, n = 64). To display the information from all the samples, overlapped markers were shifted on the x- and/or y-axis with small incremental units.
Page created: September 16, 2013
Page updated: September 16, 2013
Page reviewed: September 16, 2013
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