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Volume 19, Number 11—November 2013
Research

CTX-M β-Lactamase–producing Klebsiella pneumoniae in Suburban New York City, New York, USA

Guiqing WangComments to Author , Tiangui Huang, Pavan Kumar Makam Surendraiah, Kemeng Wang, Rashida Komal, Jian Zhuge, Chian-Ru Chern, Alexander A. Kryszuk, Cassidy King, and Gary P. Wormser
Author affiliations: New York Medical College, Valhalla, New York, USA

Main Article

Table 4

In vitro antimicrobial susceptibility of CTX-M ESBL-producing K. pneumoniae isolates, New York, 2005–2012*

Antimicrobial agent No. isolates tested No. (%) susceptible isolates MIC50 MIC90 MIC range
Cefoxitin 25 16 (64.0) ≤8 >16 <8–>16
Cefotaxime† 22 0 >256 >256 16–>256
Ceftazidime† 22 2 (9.1) 16 128 4–>256
Pip/Tazo 25 9 (36.0) 64 >64 <16–>64
Ertapenem 25 23 (92.0) <2 <2 <2–>4
Meropenem† 22 21 (95.5) 0.094 0.125 0.047–2.0
Imipenem† 22 20 (90.1) 0.25 1.5 0.19–6.0
Ciprofloxacin 25 3 (12.0) >2 >2 <1–>2
Amikacin 25 18 (72.0) <16 >32 <16–>32
Gentamicin 25 8 (32.0) >8 >8 <4–>8
Tetracycline 25 5 (20.0) >8 >8 <4–>8
TMP/SMX 25 1 (4.0) >2/38 >/38 <2/38–>2/38
Tigecycline†‡ 22 19 (86.4) 1 3 0.75– 8
Colistin†§ 22 21 (95.5) 0.25 0.38 0.19–64

*n = 25; MIC50; 50% minimum inhibitory concentration; MIC90, 90% minimum inhibitory concentration; Pip/Tazo, piperacillin/tazobactam; TMP/SMX, trimethoprim/sulfamethoxazole. MICs were determined by the MicroScan system, except for certain antimicrobial agents that were tested by Etest as specified.
†MICs were determined by Etest.
‡Susceptibility defined by Food and Drug Administration breakpoints.
§Susceptibility defined by Clinical Laboratory and Standards Institute breakpoints for Acinetobacter baumannii (19).

Main Article

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Page updated: October 31, 2013
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