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Volume 19, Number 11—November 2013
Research

Common Epidemiology of Rickettsia felis Infection and Malaria, Africa

Oleg Mediannikov1, Cristina Socolovschi1, Sophie Edouard, Florence Fenollar, Nadjet Mouffok, Hubert Bassene, Georges Diatta, Adama Tall, Hamidou Niangaly, Ogobara Doumbo, Jean Bernard Lekana-Douki, Abir Znazen, M’hammed Sarih, Pavel Ratmanov, Herve Richet, Mamadou O. Ndiath, Cheikh Sokhna, Philippe Parola, and Didier RaoultComments to Author 
Author affiliations: 1These authors contributed equally to this article.; Aix Marseille Université, Marseille, Faculté de Médecine, Marseille, France (O. Mediannikov, C. Socolovschi, S. Edouard, F. Fenollar, Patmanov P., H. Richet, P. Parola, D. Raoult); Institut de Recherche pour le Développement, Dakar, Senegal (O. Mediannikov, F. Fenollar, H. Bassene, G. Diatta, M.O. Ndiath, C. Sokhna, D. Raoult); Centre Hospitalo-Universitaire d'Oran, Oran, Algeria (N. Mouffok); Institut Pasteur de Dakar, Dakar (A. Tall); University of Sciences, Techniques and Technology, Bamako, Mali (H. Niangaly, O. Doumbo); Unité de Parasitologie Médicale Centre International de Recherche Médicale de Franceville, Franceville, Gabon (J.B. Lekana-Douki); Université des Sciences de la santé de Libreville, Libreville, Gabon (J.B. Lekana-Douki); Habib Bourguiba University Hospital, Sfax, Tunisia (A. Znazen); Institut Pasteur du Maroc, Casablanca, Morocco (M. Sarih); Far Eastern State Medical University, Khabarovsk, Russia (P. Ratmanov)

Main Article

Table 4

Detection of Rickettsia species in arthropods collected in Senegal, 2008–2012

Group Species No. samples tested Type of rickettsia (% positive samples) Reference
Fleas
Ctenocephalides felis 48 None (13)
Echidnophaga gallinacea 150 None
Synosternus pallidus
41
Rickettsia sp., group R. felis (93)
Tsetse flies
Glossina morsitans submorsitans
78
Rickettsia sp., group R. felis (100)
(30)
Hard ticks
Amblyomma variegatum 492 Rickettsia africae (87)
(29)
Rhipicephalus decoloratus 40 Rickettsiae spotted fever group (0–51)
(27)
R. annulatus 5
Hyalomma marginatum rufipes 173
H. truncatum 141
R. evertsi evertsi 2358
R. guilhoni
50
Rhipicephalus sp.
2
None
This study
Soft ticks
Ornithodoros sonrai 138 None This study
O. capensis 40 Rickettsia sp., group R. felis (20) This study
Argas persicus
4
None
This study
Midges
Culicoides spp.
384
None
This study
Bed bugs Cimex hemipterus 160 1/160, (0.6) This study

Main Article

References
  1. Parola  P, Diatta  G, Socolovschi  C, Mediannikov  O, Tall  A, Bassene  H, Tick-borne relapsing fever borreliosis, rural Senegal. Emerg Infect Dis. 2011;17:883–5. PubMed DOI
  2. Reddy  EA, Shaw  AV, Crump  JA. Community-acquired bloodstream infections in Africa: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10:417–32. PubMed DOI
  3. Fenollar  F, Mediannikov  O, Socolovschi  C, Bassene  H, Diatta  G, Richet  H, Tropheryma whipplei bacteremia during fever in rural west Africa. Clin Infect Dis. 2010;51:515–21. PubMed DOI
  4. Socolovschi  C, Mediannikov  O, Sokhna  C, Tall  A, Diatta  G, Bassene  H, Rickettsia felis-associated uneruptive fever, Senegal. Emerg Infect Dis. 2010;16:1140–2. PubMed DOI
  5. Maina  AN, Knobel  DL, Jiang  J, Halliday  J, Feikin  DR, Cleaveland  S, Rickettsia felis infection in febrile patients, Western Kenya, 2007–2010. Emerg Infect Dis. 2012;18:328–31. PubMed DOI
  6. Richards  AL, Jiang  J, Omulo  S, Dare  R, Abdirahman  K, Ali  A, Human infection with Rickettsia felis, Kenya. Emerg Infect Dis. 2010;16:1081–6. PubMed DOI
  7. Mediannikov  O, Fenollar  F, Socolovschi  C, Diatta  G, Sokhna  C, Bassene  H, Coxiella burnetii in humans and ticks in rural Senegal. PLoS Negl Trop Dis. 2010;4:e654. PubMed DOI
  8. Reller  ME, Clemens  EG, Schachterle  SE, Mtove  GA, Sullivan  DJ, Dumler  JS. Multiplex 5′ nuclease-quantitative PCR for diagnosis of relapsing fever in a large Tanzanian cohort. J Clin Microbiol. 2011;49:3245–9. PubMed DOI
  9. Freedman  DO, Weld  LH, Kozarsky  PE, Fisk  T, Robins  R, von Sonnenburg  F, Spectrum of disease and relation to place of exposure among ill returned travelers. N Engl J Med. 2006;354:119–30. PubMed DOI
  10. Tourism Highlights United Nations World Tourism Organization [cited 2013 May 15]. http://mkt.unwto.org/sites/all/files/docpdf/unwtohighlights11enhr_3.pdf. 2011
  11. Wilson  ME, Weld  LH, Boggild  A, Keystone  JS, Kain  KC, von Sonnenburg  F, Fever in returned travelers: results from the GeoSentinel Surveillance Network. Clin Infect Dis. 2007;44:1560–8. PubMed DOI
  12. Mediannikov  O, Fenollar  F, Bassene  H, Tall  A, Sokhna  C, Trape  JF, Description of “yaaf”, the vesicular fever caused by acute Rickettsia felis infection in Senegal. J Infect. 2013;66:536-40. PubMed DOI
  13. Roucher  C, Mediannikov  O, Diatta  G, Trape  JF, Raoult  D. A new Rickettsia species found in fleas collected from human dwellings and from domestic cats and dogs in Senegal. [PubMed ]. Vector Borne Zoonotic Dis. 2012;12:3605. DOIPubMed
  14. Raoult  D, Roux  V. Rickettsioses as paradigms of new or emerging infectious diseases. [PubMed]. Clin Microbiol Rev. 1997;10:694719.PubMed
  15. Verhulst  NO, Smallegange  RC, Takken  W. Mosquitoes as potential bridge vectors of malaria parasites from non-human primates to humans. Front Physiol. 2012;3:197. PubMed DOI
  16. Duval  L, Fourment  M, Nerrienet  E, Rousset  D, Sadeuh  SA, Goodman  SM, African apes as reservoirs of Plasmodium falciparum and the origin and diversification of the Laverania subgenus. Proc Natl Acad Sci U S A. 2010;107:10561–6. PubMed DOI
  17. Socolovschi  C, Pages  F, Ndiath  MO, Ratmanov  P, Raoult  D. Rickettsia species in African Anopheles mosquitoes. PLoS ONE. 2012;7:e48254. PubMed DOI
  18. Socolovschi  C, Pages  F, Raoult  D. Rickettsia felis in Aedes albopictus mosquitoes, Libreville, Gabon. Emerg Infect Dis. 2012;18:1687–9. PubMed DOI
  19. Keita  AK, Socolovschi  C, Ahuka-Mundeke  S, Ratmanov  P, Butel  C, Ayouba  A, Molecular evidence for the presence of Rickettsia felis in the feces of wild-living African apes. PLoS ONE. 2013;8:e54679. PubMed DOI
  20. Trape  JF, Rogier  C, Konate  L, Diagne  N, Bouganali  H, Canque  B, The Dielmo project: a longitudinal study of natural malaria infection and the mechanisms of protective immunity in a community living in a holoendemic area of Senegal. [PubMed]. Am J Trop Med Hyg. 1994;51:12337.PubMed
  21. Rolain  JM, Bitam  I, Buffet  S, Marie  JL, Bourry  O, Portelli-Clerc  C, Presence or absence of plasmid in Rickettsia felis depending on the source of fleas. Clin Microbiol Infect. 2009;Suppl 2:296–7. PubMed DOI
  22. Ndao  M, Bandyayera  E, Kokoskin  E, Gyorkos  TW, MacLean  JD, Ward  BJ. Comparison of blood smear, antigen detection, and nested-PCR methods for screening refugees from regions where malaria is endemic after a malaria outbreak in Quebec, Canada. J Clin Microbiol. 2004;42:2694–700. PubMed DOI
  23. Sigaúque  B, Roca  A, Mandomando  I, Morais  L, Quinto  L, Sacarlal  J, Community-acquired bacteremia among children admitted to a rural hospital in Mozambique. Pediatr Infect Dis J. 2009;28:108–13. PubMed DOI
  24. Okwara  FN, Obimbo  EM, Wafula  EM, Murila  FV. Bacteraemia, urinary tract infection and malaria in hospitalised febrile children in Nairobi: is there an association? East Afr Med J. 2004;81:47–51. PubMed DOI
  25. Phommasone  K, Haris  DH, Anantatat  T, Castonguay-Vanier  J, Keomany  S, Souvannasing  P, Concurrent infection with murine typhus and scrub typhus in southern Laos—the mixed and the unmixed. PLoS Negl Trop Dis. 2013;7:e2163. DOIPubMed
  26. Roucher  C, Rogier  C, Dieye-Ba  F, Sokhna  C, Tall  A, Trape  JF. Changing malaria epidemiology and diagnostic criteria for Plasmodium falciparum clinical malaria. PLoS ONE. 2012;7:e46188. PubMed DOI
  27. Mediannikov  O, Diatta  G, Fenollar  F, Sokhna  C, Trape  JF, Raoult  D. Tick-borne rickettsioses, neglected emerging diseases in rural Senegal. PLoS Negl Trop Dis. 2010;4. PubMed DOI
  28. Niang  MN, Dosseh  A, Ndiaye  K, Sagna  M, Gregory  V, Goudiaby  D, Sentinel surveillance for influenza in Senegal, 1996–2009. J Infect Dis. 2012;206(Suppl 1):S129–35. PubMed DOI
  29. Mediannikov  O, Trape  JF, Diatta  G, Parola  P, Fournier  PE, Raoult  D. Rickettsia africae, a neglected pathogen in West Africa. Emerg Infect Dis. 2010;16:571–3. PubMed DOI
  30. Mediannikov  O, Audoly  G, Diatta  G, Trape  JF, Raoult  D. New Rickettsia sp. in tsetse flies from Senegal. [PubMed ]. Comp Immunol Microbiol Infect Dis. 2012;35:14550. DOIPubMed
  31. Abdad  MY, Stenos  J, Graves  S. Rickettsia felis, an emerging flea-transmitted human pathogen. Emerg Health Threats J. 2011;4:7168
  32. Zavala-Velázquez  JE, Sosa-Ruiz  JA, Zavala-Castro  J, Jimenez-Delgadillo  B, Vado-Solis  IE, Sanchez-Elias  RA, Rickettsia felis— the etiologic agent of three cases of rickettsiosis in Yucatan. Lancet. 2000;356:1079–80. PubMed DOI
  33. Twartz  JC, Shirai  A, Selvaraju  G, Saunders  JP, Huxsoll  DL, Groves  MG. Doxycycline propylaxis for human scrub typhus. J Infect Dis. 1982;146:811–8. PubMed DOI

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Page updated: October 31, 2013
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