Volume 19, Number 11—November 2013
Dispatch
Three Outbreak-causing Neisseria meningitidis Serogroup C Clones, Brazil1
David E. Barroso
, Terezinha M.P.P. Castiñeiras, Fernanda S. Freitas, Jane W. Marsh, Mary G. Krauland, Mary M. Tulenko, Érica L. Fonseca, Ana C.P. Vicente, Maria C. Rebelo, Elaine O. Cerqueira, Adriano C. Xavier, Ana P.C.M. Cardozo, Simone E.M. da Silva, and Lee H. Harrison
, Terezinha M.P.P. Castiñeiras, Fernanda S. Freitas, Jane W. Marsh, Mary G. Krauland, Mary M. Tulenko, Érica L. Fonseca, Ana C.P. Vicente, Maria C. Rebelo, Elaine O. Cerqueira, Adriano C. Xavier, Ana P.C.M. Cardozo, Simone E.M. da Silva, and Lee H. Harrison
Table
Genotyping of serogroup C Neisseria meningitidis invasive isolates recovered from 1990 to 2010 with timeline showing when the cluster-associated clone were first observed in Rio de Janeiro State, Brazil
| Serogroup/year | Genotype (no. isolates)/clonal complex | Date of emergence of cluster-related clone (date of commencement of cluster) | |
|---|---|---|---|
| C:2a | ST-11 | ||
| 1990 | 2-184:P1.5-1,2-2:F1-1:ST-5121 (1) | ||
| 1995–1997 | 2-2:P1.5,2:F3-6:ST-11 (5) | ||
| 1997 | 2-60:P1.5,2:F3-6:ST-7849 (1) | ||
| 2000 | 2-145:P1.5,2:F1-1:ST-11 (1) | ||
| 2001 | 2-184:P1.5-1,2-2:F1-1:ST-5121 (1) | ||
| 2007–2009 | 2-2:P1.5-1,10-8:F3-6:ST-11 (9) | February 2007 (February 2007, January 2008) | |
| 2009 | 2-2:P1.5-1,5-11:F3-6:ST-11 (1) | ||
| 2010 |
2-2:P1.5-1,10-8:F3-6:ST-9452 (3) |
May 2010 (May 2010) |
|
| C:2b | ST-8 | ||
| 1990 | 2-3:P1.18-1,3:F3-1:ST-8 (1) | No cluster associated with this clonal complex | |
| 1992 | 2-3:P1.18-1,3:F3-9:ST-8 (2) | ||
| 1995–1997 | 2-30:P1.5-2,10:F5-2:ST-8 (1) | ||
| 2-3:P1.18-1,3:F3-1:ST-8 (1) | |||
| 2-30:5-2,10:F5-2:ST-153 (8)* | |||
| 2-3:18-1,3:F3-9:ST-7769 (1) | |||
| 2-30:5-2,10:F5-2:ST-7713 (1) | |||
| 2002† | 2-30:5-2,10:F5-2:ST-153 (1) | ||
| 2-30:5-2,10:F5-2:ST-7705 (1) |
|||
| C:4,7 | ST-32 | ||
| 1994 | 3-1:P1.19,15:F5-1:ST-7709 (1) | ||
| 1998–2010 | 3-79:P1.7-1,1:F5-1:ST-639 (16) | June 1998 (July 2009) | |
| 3-1:P1.19,15:F1-80:ST-33 (1) | |||
| 3-299:P1.7-1,1:F5-1:ST-639 (2) | |||
| 3-1:P1.19,15:F5-1:ST-33 (2) | |||
| 3-79:P1.19,15:F5-1:ST-639 (1) | |||
| 3-1:P1.19,15:F5-1:ST-34 (1) | |||
| 3-1:P1.19,15:F5-1:ST-639 (3) | |||
| 3-79:P1.7-1,1:F5-1:ST-7692 (1) | |||
| 3-79:P1.7-1,1:F5-1:ST-7696 (1) | October 2006 (October 2006) | ||
| 3-294:P1.7-1,1:F5-1:ST-639 (1) |
|||
| 2007 | 3-300:P1.18-1,3:F5-37:ST-41 (1) | No cluster associated with this clonal complex | |
| C:4,7 | No clonal complex | ||
| 1993–1994 | 3-27:P1.20,9:F1-7:ST-7690 (3) | No cluster associated with these strains | |
| 3-1:P1.21,16:F1-20:ST-7712 (1) | |||
| 2003 | 3-1:P1.5,15:F4-3:ST-7691 (1) | ||
| C:19 | ST-41/44, ST-174, and ST-269 | ||
| 1993–1995 | 3-295:P1.5-1,10-4:F4-21:ST-3772 (1) | No cluster associated with these clonal complexes | |
| 3-295:P1.5-1,10-4:F5-1:ST-3772 (1) | |||
| 2007 | 3-35:P1.21,16:F5-13:ST-7817 (1) | ||
| 3-71:P1.19,15:F5-2:ST-437 (1) | |||
| C:23 | ST-103 | ||
| 2001–2010 | 2-23:P1.22,14-6:F1-80:ST-3779 (1) | ||
| 2-23:P1.22,14-6:F3-9:ST-3779 (13) | July 2001 (February 2012) | ||
| 2-23:P1.22,14-6:F5-92:ST-7689 (1) | |||
| 2-23:P1.22,14-6:F3-9:ST-3780 (14) | July 2003 (April 2012) | ||
| 2-23:P1.22,14-6:F1-5:ST-5727 (1) | |||
| 2-23:P1.22,14-6:F3-9:ST-7708 (1) | September 2003 (September 2003) | ||
| 2-23:P1.5,14-6:F3-9:ST-5122 (1) | |||
| 2-23:P1.22,14-6:F3-9:ST-5122 (2) | |||
| 2-23:P1.22,14-6:F5-92:ST-5338 (1) | |||
| 2-167:P1.22,14-6:F3-9:ST-3779 (3) | |||
| 2-23:P1.18-1,3:F3-9:ST-3779 (3) | |||
| 2-23:P1.22,14-6:F3-9:ST-8732 (1) | |||
| C:23 | No clonal complex | ||
| 2010 | 2-23:P1.22,14-6:F3-9:ST-8730 (1) | No cluster associated with this strain | |
*No invasive C:2b isolate has been recovered since 2002.
†The clone associated with the last epidemic of serogroup C disease in 1994.
1The study was presented in part in the 18th International Pathogenic Neisseria Conference, September 9–14, 2012, Würzburg, Germany.
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