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Volume 19, Number 11—November 2013

Full Genome of Influenza A (H7N9) Virus Derived by Direct Sequencing without Culture

Xianwen Ren1, Fan Yang1, Yongfeng Hu1, Ting Zhang1, Liguo Liu1, Jie Dong, Lilian Sun, Yafang Zhu, Yan Xiao, Li Li, Jian Yang, Jianwei Wang, and Qi JinComments to Author 
Author affiliations: MOH Key Laboratory of Systems Biology of Pathogens, Beijing, China

Main Article

Table 1

Mutations of directly sequenced influenza A (H7N9) virus and that obtained from chicken egg culture*

Gene Position Direct sequencing Chicken egg culture Amino acid change
PB2 18 A G Synonymous
PB2 1601 C T S534F
PB1 303 G A Synonymous
PB1 825 G A Synonymous
PB1 2274 A G Synonymous
PA 2115 G T Synonymous
PA 2119 G T V707F
PA 2127 A C Synonymous
NS 176 G A R59H in NS1
NS 792 C T P107L in NS2
NS 803 G C Synonymous
NS 804 T A Synonymous
NS 805 C A V111Q in NS2
NP 387 A T Synonymous
NP 438 T C Synonymous
NP 480 T C Synonymous
NP 648 A G Synonymous
NP 657 T C Synonymous
NP 663 A G Synonymous
NP 892 T C Synonymous
NP 962 G A S321N
NP 982 C T Synonymous
NP 1086 G A Synonymous
NP 1113 G A M371I
NP 1200 G A Synonymous
NP 1251 C T Synonymous
NP 1257 T C Synonymous
*PB, polymerase basic; PA, polymerase acidic; NS, nonstructural; NP, nucleocapsid protein.

Main Article

1These authors contributed equally to this article.

Page created: August 15, 2013
Page updated: October 29, 2013
Page reviewed: October 29, 2013
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