Volume 19, Number 11—November 2013
Dispatch
Full Genome of Influenza A (H7N9) Virus Derived by Direct Sequencing without Culture
Table 2
Protein | Heterogeneity, nucleotide position in gene sequence: nucleotides)† | Amino acid position in protein sequence‡ | Direct sequencing§ | Culture§# | A/Anhui/1/2013§ | Consensus of isolate from humans§** |
---|---|---|---|---|---|---|
HA | 330: C>T | 110 | F | F | F | F |
HA | 360: C>T | 120 | L | L | L | L |
HA | 696: T>A | 232 | V | V | V | V |
HA | 724: C>T | 242 | H242Y | H | H | H |
HA | 762: C>T | 254 | F | F | F | F |
HA | 780: C>T | 260 | F | F | F | F |
HA | 1441: C>T | 481 | H | H | H | H |
HA | 65 | M | M | R | R | |
M2 | 10 | L | L | P | P | |
M2 | 24 | D | D | E | E | |
NA | 275: C>T | 92 | S92L | S | S | S |
NA | 323: C>T | 108 | S108L | S | S | S |
NA | 408: C>T | 136 | I | I | I | I |
NA | 40 | S | S | G | G | |
NA | 300 | V | V | I | I | |
NA | 340 | I | I | N | N | |
NP | 321 | S | N | N | N | |
NP | 858: C>T | 286 | A | A | A | A |
NP | 583: G>A | 195 | R | R | R | R |
NP | 1261: G = A | 421 | E421K | E | E | E |
NP | 1260: C = T | 420 | F | F | F | F |
NP | 371 | M | I | M | M | |
NS2 | 546: C>>T | 55 | L | L | L | L |
NS2 | 543: C>>T | 54 | D | D | D | D |
NS1 | 418: C>>T | 140 | R140W | R | R | R |
NS1 | 59 | R | H | R | R | |
NS2 | 107 | P | L | L | L | |
NS2 | 111 | V | Q | Q | Q | |
PA | 174: C>A | 58 | G | G | G | G |
PA | 1305:C>T | 435 | I | I | I | I |
PA | 618 | K | K | T | T | |
PA | 707 | V | F | F | F | |
PB1 | 200 | I | I | V | V | |
PB1 | 368 | I | I | V | V | |
PB1 | 454 | L | L | P | P | |
PB1 | 637 | V | V | I | I | |
PB1-F2 | 42 | C | C | Y | Y | |
PB1-F2 | 51 | T | T | M | M | |
PB1-F2 | 70 | G | E | G | G | |
PB1-F2 | 77 | L | L | S | S | |
PB2 | 534 | S | F | S | S | |
PB2 | 591 | K | K | Q | Q | |
PB2 | 627 | E | E | K | K |
*HA, hemagglutinin; M, matrix; NA, neuraminidase; NP, nucleocapsid protein; NS, nonstructural; PA, polymerase acidic; PB,
polymerase basic.
†Position of first nucleotide = 1.
‡Position of first amino acid = 1.
§Types of amino acids.
#Virus cultured in chicken eggs.
**Thirteen influenza A (H7N9) viruses isolated from humans; data from Global Initiative on Sharing All Influenza Data.
1These authors contributed equally to this article.
Page created: August 15, 2013
Page updated: October 29, 2013
Page reviewed: October 29, 2013
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