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Volume 19, Number 12—December 2013
Conference Summary

Toward Proof of Concept of a One Health Approach to Disease Prediction and Control

Peter M. Rabinowitz1Comments to Author , Richard Kock, Malika Kachani, Rebekah Kunkel, Jason Thomas, Jeffrey Gilbert, Robert Wallace, Carina Blackmore, David Wong, William Karesh, Barbara Natterson, Raymond Dugas, Carol Rubin, and for the Stone Mountain One Health Proof of Concept Working Group
Author affiliations: Yale University School of Medicine, New Haven, Connecticut, USA (P.M. Rabinowitz); University of London, London, UK (R. Kock); Western University of Health Sciences, Pomona, California, USA (M. Kachani); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (R. Kunkel, J. Thomas, C. Rubin); International Livestock Research Institute, Vientiane, Laos (J. Gilbert); University of Minnesota, Minneapolis, Minnesota, USA (R. Wallace); Florida Department of Public Health, Tallahassee, Florida, USA (C. Blackmore); National Park Service, Washington, DC, USA (D. Wong); Ecohealth Alliance, New York, New York, USA (W. Karesh); University of California Los Angeles Medical Center, Los Angeles, California, USA (B. Natterson); Pan American Health Organization/Panaftosa, Santiago, Chile (R. Dugas); 1Current affiliation: University of Washington, Seattle, Washington, USA.

Main Article

One Health Concept Evidence in support of concept Study type Reference
It is feasible to integrate human, animal, and environmental health efforts.
Reports of animal illness facilitated investigation of human cases caused by toxic environmental chemicals.
Case report
14
Animal and human cases of Cryptococcus gattii infection can help identify environmental risk for infection.
Case report
15
Collaboration between public health and wildlife health agencies enabled simultaneous testing of bats for rabies and white nose syndrome.
Case report
16
A mathematical model showed proof of concept for an integrated approach to avian influenza control.
Disease model
17
Sheep and cattle deaths helped trace release of weaponized anthrax.
Case report
18
Integrated approaches that consider human, animal, and environmental health components can improve prediction of certain diseases.
Cattle poisonings caused by lead exposure in the soil helped detect cases of lead poisoning in humans living nearby.
Case report
19
Household pets served as sentinels for childhood lead poisoning risk.
Case report
20
A household bird provided warning of carbon monoxide poisoning to household members.
Case report
21
A prediction model incorporating bird, mosquito, and climate data was superior to less integrated models for predicting human infection with West Nile virus in Los Angeles, California.
Retrospective case cross-over study
22
Climate based models predicted Rift Valley fever in humans and animals.
Prospective observational study
23
Seasonal temperatures predicted risk for campylobacteriosis in chickens and humans.
Retrospective longitudinal study
24
Integrated approaches that consider human, animal, and environmental health components can improve control of certain diseases. Enhanced mechanized ventilation in a horse stable led to improvements in indoor air quality and in the respiratory health of horses and humans.
Case report
25
Reduced cases of poultry and human campylobacteriosis in Iceland over a multiyear period was attributed to better on-farm biosecurity measures and public education.
Retrospective longitudinal study
26
Rates of human infection with Schistosoma japonicum were lower when treatment was given to humans and domestic buffaloes than when treatment was given to humans only.
Controlled intervention study
27,28
Environmental interventions helped reduce human, animal, and environmental rates of S. japonicum infection.
Controlled intervention study
29
The spread of methicillin-resistant Staphylococcus aureus infection in a horse hospital was stopped by environmental cleaning and isolation of animals and humans. Case report 30

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References
  1. Taylor  LH, Latham  SM, Woolhouse  ME. Risk factors for human disease emergence. Philos Trans R Soc Lond B Biol Sci. 2001;356:9839. DOIPubMed
  2. Woolhouse  ME, Gowtage-Sequeria  S. Host range and emerging and reemerging pathogens. Emerg Infect Dis. 2005;11:18427. DOIPubMed
  3. Daszak  P, Zambrana-Torrelio  C, Bogich  TL, Fernandez  M, Epstein  JH, Murray  KA, Interdisciplinary approaches to understanding disease emergence: the past, present, and future drivers of Nipah virus emergence. Proc Natl Acad Sci U S A. 2013;110(Suppl 1):36818 . DOIPubMed
  4. Rabinowitz  P, Scotch  M, Conti  L. Human and animal sentinels for shared health risks. Vet Ital. 2009;45:234 .PubMed
  5. Kahn  LH. The need for One Health degree programs. Infection Ecology and Epidemiology. 2011;1:7919.
  6. Karesh  WB, Dobson  A, Lloyd-Smith  JO, Lubroth  J, Dixon  MA, Bennett  M, Ecology of zoonoses: natural and unnatural histories. Lancet. 2012;380:193645. DOIPubMed
  7. Institute of Medicine. Forum on Microbial Threats, Board on Global Health, Improving Food Safety Through a One Health Approach: workshop summary. Washington (DC): National Academies Press; 2012.
  8. Serra  AL, Kistler  AD, Poster  D, Struker  M, Wüthrich  RP, Weishaupt  D, Clinical proof-of-concept trial to assess the therapeutic effect of sirolimus in patients with autosomal dominant polycystic kidney disease: SUISSE ADPKD study. BMC Nephrol. 2007;8:13. DOIPubMed
  9. Aagaard  E, Teherani  A, Irby  DM. Effectiveness of the one-minute preceptor model for diagnosing the patient and the learner: proof of concept. Acad Med. 2004;79:429 . DOIPubMed
  10. Wolever  RQ, Bobinet  KJ, McCabe  K, Mackenzie  ER, Fekete  E, Kusnick  CA, Effective and viable mind–body stress reduction in the workplace: a randomized controlled trial. J Occup Health Psychol. 2012;17:24658. DOIPubMed
  11. Lowton  K, Laybourne  AH, Whiting  DG, Martin  FC. Can fire and rescue services and the National Health Service work together to improve the safety and wellbeing of vulnerable older people? Design of a proof of concept study. BMC Health Serv Res. 2010;10:327. DOIPubMed
  12. Schwabe  CW. Veterinary medicine and human health. Baltimore: Williams & Wilkins; 1964.
  13. Mazet  JA, Clifford  DL, Coppolillo  PB, Deolalikar  AB, Erickson  JD, Kazwala  RRAA. “One Health” approach to address emerging zoonoses: the HALI project in Tanzania. PLoS Med. 2009;6:e1000190 and. DOIPubMed
  14. Buttke  DE. Toxicology, environmental health, and the “One Health” concept. J Med Toxicol. 2011;7:32932. DOIPubMed
  15. Mak  S, Klinkenberg  B, Bartlett  K, Fyfe  M. Ecological niche modeling of Cryptococcus gattii in British Columbia, Canada. Environ Health Perspect. 2010;118:6538 . DOIPubMed
  16. Griggs  A, Keel  MK, Castle  K, Wong  D. Enhanced surveillance for white-nose syndrome in bats. Emerg Infect Dis. 2012;18:5302. DOIPubMed
  17. Guan  Y, Chen  H, Li  K, Riley  S, Leung  G, Webster  R, A model to control the epidemic of H5N1 influenza at the source. BMC Infect Dis. 2007;7:132. DOIPubMed
  18. Meselson  M, Guillemin  J, Hugh-Jones  M, Langmuir  A, Popova  I, Shelokov  A, The Sverdlovsk anthrax outbreak of 1979. Science. 1994;266:12028. DOIPubMed
  19. Bischoff  K, Priest  H, Mount-Long  A. Animals as sentinels for human lead exposure: a case report. J Med Toxicol. 2010;6:1859. DOIPubMed
  20. Dowsett  R, Shannon  M. Childhood plumbism identified after lead poisoning in household pets. N Engl J Med. 1994;331:16612. DOIPubMed
  21. Mutluoğlu  M, Uzun  G, Eroglu  M, Ay  H. Domestic animals as a warning sign for carbon monoxide poisoning. Pediatr Emerg Care. 2012;28:596. DOIPubMed
  22. Kwan  JL, Park  BK, Carpenter  TE, Ngo  V, Civen  R, Reisen  WK. Comparison of enzootic risk measures for predicting West Nile disease, Los Angeles, California, USA, 2004–2010. Emerg Infect Dis. 2012;18:1298306 and. DOIPubMed
  23. Anyamba  A, Chretien  JP, Small  J, Tucker  CJ, Formenty  PB, Richardson  JH, Prediction of a Rift Valley fever outbreak. Proc Natl Acad Sci U S A. 2009;106:9559. DOIPubMed
  24. Jore  S, Viljugrein  H, Brun  E, Heier  BT, Borck  B, Ethelberg  S, Trends in Campylobacter incidence in broilers and humans in six European countries, 1997–2007. Prev Vet Med. 2010;93:3341. DOIPubMed
  25. Wålinder  R, Riihimäki  M, Bohlin  S, Hogstedt  C, Nordquist  T, Raine  A, Installation of mechanical ventilation in a horse stable: effects on air quality and human and equine airways. Environ Health Prev Med. 2011;16:26472. DOIPubMed
  26. Stern  NJ, Hiett  KL, Alfredsson  GA, Kristinsson  KG, Reiersen  J, Hardardottir  H, Campylobacter spp. in Icelandic poultry operations and human disease. Epidemiol Infect. 2003;130:2332. DOIPubMed
  27. Gray  DJ, Williams  GM, Li  Y, Chen  H, Forsyth  SJ, Li  RS, A cluster-randomised intervention trial against Schistosoma japonicum in the People’s Republic of China: bovine and human transmission. PLoS One. 2009;12:4:e5900. PubMed
  28. Guo  J, Li  Y, Gray  D, Ning  A, Hu  G, Chen  H, A drug-based intervention study on the importance of buffaloes for human Schistosoma japonicum infection around Poyang Lake, People’s Republic of China. Am J Trop Med Hyg. 2006;74:33541 .PubMed
  29. Wang  LD, Chen  HG, Guo  JG, Zeng  XJ, Hong  XL, Xiong  JJ, A strategy to control transmission of Schistosoma japonicum in China. N Engl J Med. 2009;360:1218. DOIPubMed
  30. van Duijkeren  E, Moleman  M, Sloet van Oldruitenborgh-Oosterbaan  MM, Multem  J, Troelstra  A, Fluit  AC, Methicillin-resistant Staphylococcus aureus in horses and horse personnel: an investigation of several outbreaks. Vet Microbiol. 2010;141:96102. DOIPubMed
  31. Schelling  E, Bechir  M, Ahmed  MA, Wyss  K, Randolph  TF, Zinsstag  J. Human and animal vaccination delivery to remote nomadic families, Chad. Emerg Infect Dis. 2007;13:3739. DOIPubMed
  32. Cleaveland  S, Kaare  M, Tiringa  P, Mlengeya  T, Barrat  J. A dog rabies vaccination campaign in rural Africa: impact on the incidence of dog rabies and human dog-bite injuries. Vaccine. 2003;21:196573. DOIPubMed
  33. Kushner  RF, Blatner  DJ, Jewell  DE, Rudloff  K. The PPET Study: people and pets exercising together. Obesity (Silver Spring). 2006;14:176270. DOIPubMed
  34. Oberhelman  RA, Gilman  RH, Sheen  P, Cordova  J, Zimic  M, Cabrera  L, An intervention-control study of corralling of free-ranging chickens to control Campylobacter infections among children in a Peruvian periurban shantytown. Am J Trop Med Hyg. 2006;74:10549 .PubMed
  35. World Health Organization. The control of neglected zoonotic diseases. A route to poverty alleviation. Report of a joint WHO/DFID-AHP meeting; 2005 Sep 20–21; Geneva. Geneva: The Organization;2006.
  36. World Health Organization. Integrated control of neglected zoonotic diseases in Africa. Adapting the “One Health” concept. Report of a WHO/EU/ILRI/DBL/FAO/AU IIRI meeting; 2007 Nov 13–15; Nairobi, Kenya. Geneva: The Organization;2009.
  37. National Research Council. Sustaining global surveillance and response to emerging zoonotic diseases. Washington (DC): National Academies Press; 2009.
  38. Scotch  M, Brownstein  JS, Vegso  S, Galusha  D, Rabinowitz  P. Human vs. animal outbreaks of the 2009 swine-origin H1N1 influenza A epidemic. EcoHealth. 2011;8:37680. DOIPubMed
  39. Rojas  CA. An ecosystem approach to human health and the prevention of cutaneous leishmaniasis in Tumaco, Colombia. Cad Saude Publica. 2001;17(Suppl):193200. DOIPubMed
  40. Pilger  D, Schwalfenberg  S, Heukelbach  J, Witt  L, Mencke  N, Khakban  A, Controlling tungiasis in an impoverished community: an intervention study. PLoS Negl Trop Dis. 2008;2:e324. DOIPubMed

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Page created: November 08, 2013
Page updated: November 08, 2013
Page reviewed: November 08, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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