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Volume 19, Number 12—December 2013
Dispatch

Novel Cause of Tuberculosis in Meerkats, South Africa

Sven D.C. ParsonsComments to Author , Julian A. Drewe, Nicolaas C. Gey van Pittius, Robin M. Warren, and Paul D. van Helden
Author affiliations: Stellenbosch University, Tygerberg, South Africa (S.D.C. Parsons, N.C. Gey van Pittius, R.M. Warren, P.D. van Helden); Royal Veterinary College, London, UK (J.A. Drewe); South African Medical Research Council, Cape Town, South Africa (R.M. Warren, P.D. van Helden)

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Table 2

MIRU-VNTR patterns of Mycobacterium suricattae and representative isolates of selected members of the M. tuberculosis complex*

Locus MIRU-VNTR copy number
M. africanum† M. mungi† M. suricattae Dassie bacillus†
MIRU 2 2 2 2 2
VNTR 424/Mtub04 4 3 3‡, 2§ 2
VNTR 577/ETR-C 5 3 5 5
MIRU 4/ETR-D 2 3 2 3
MIRU 40 2 1 2 2
MIRU 10 7 5 6 7
MIRU 16 4 3 2 3
VNTR 1955/Mtub21 4 3 3 3
MIRU 20 2 2 2 2
VNTR 2163b/QUB11b 5 – – 7
VNTR 2165/ETR-A 6 6 – 6
VNTR2347/Mtub29 3 3 3 3
VNTR 2401/Mtub30 4 4 4‡, 5§ 3
VNTR 2461/ETR-B 4 4 5 4
MIRU 23 4 4 4 4
MIRU 24 2 2 3 2
MIRU 26 4 4 4 5
MIRU 27 3 3 1 4
VNTR 3171/Mtub 34 3 3 3 3
MIRU 31/ETR-E 5 8 and 9 5 5
VNTR 3690/Mtub 39 4 – 8 5
VNTR 4052/QUB 26 6 – 3 4
VNTR 4156/QUB 4156 3 – 1 3
MIRU 39 2 2 2 2

*MIRU-VNTR, mycobacterial interspersed repetitive unit–variable number tandem repeats; –, no amplification.
†From Alexander et al., 2010 (4).
‡Copy number of 3 isolates from 2 meerkats, including MK172.
§Copy number of a fourth isolate from a third meerkat.

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References
  1. Smith  NH, Kremer  K, Inwald  J, Dale  J, Driscoll  JR, Gordon  SV, Ecotypes of the Mycobacterium tuberculosis complex. J Theor Biol. 2006;239:220–5 . DOIPubMed
  2. Huard  RC, Fabre  M, de Haas  P, Lazzarini  LC, van Soolingen  D, Cousins  D, Novel genetic polymorphisms that further delineate the phylogeny of the Mycobacterium tuberculosis complex. J Bacteriol. 2006;188:4271–87. DOIPubMed
  3. Michel  AL, Müller  B, van Helden  PD. Mycobacterium bovis at the animal–human interface: a problem, or not? Vet Microbiol. 2010;140:371–81. DOIPubMed
  4. Cousins  DV, Peet  RL, Gaynor  WT, Williams  SN, Gow  BL. Tuberculosis in imported hyrax (Procavia capensis) caused by an unusual variant belonging to the Mycobacterium tuberculosis complex. Vet Microbiol. 1994;42:135–45. DOIPubMed
  5. Mostowy  S, Cousins  D, Behr  MA. Genomic interrogation of the dassie bacillus reveals it as a unique RD1 mutant within the Mycobacterium tuberculosis complex. J Bacteriol. 2004;186:104–9. DOIPubMed
  6. Alexander  KA, Laver  PN, Michel  AL, Williams  M, van Helden  PD, Warren  RM, Novel Mycobacterium tuberculosis complex pathogen, M. mungi. Emerg Infect Dis. 2010;16:1296–9 . DOIPubMed
  7. Alexander  KA, Pleydell  E, Williams  MC, Lane  EP, Nyange  JF, Michel  AL. Mycobacterium tuberculosis: an emerging disease of free-ranging wildlife. Emerg Infect Dis. 2002;8:598–601 . DOIPubMed
  8. Drewe  JA, Foote  AK, Sutcliffe  RL, Pearce  GP. Pathology of Mycobacterium bovis infection in wild meerkats (Suricata suricatta). J Comp Pathol. 2009;140:12–24. DOIPubMed
  9. Drewe  JA. Who infects whom? Social networks and tuberculosis transmission in wild meerkats. Proc Biol Sci. 2010;277:633–42. DOIPubMed
  10. Drewe  JA, Eames  KTD, Madden  JR, Pearce  GP. Integrating contact network structure into tuberculosis epidemiology in meerkats in South Africa: implications for control. Prev Vet Med. 2011;101:113–20. DOIPubMed
  11. Warren  RM, Gey van Pittius  NC, Barnard  M, Hesseling  A, Engelke  E, de Kock  M, Differentiation of Mycobacterium tuberculosis complex by PCR amplification of genomic regions of difference. Int J Tuberc Lung Dis. 2006;10:818–22 .PubMed
  12. Warren  RM, van Helden  PD, Gey van Pittius  NC. Insertion element IS6110-based restriction fragment length polymorphism genotyping of Mycobacterium tuberculosis. Methods Mol Biol. 2009;465:353–70 .DOIPubMed
  13. Kamerbeek  J, Schouls  L, Kolk  A, van Agterveld  M, van Soolingen  D, Kuijper  S, Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J Clin Microbiol. 1997;35:907–14 .PubMed
  14. Harmsen  D, Dostal  S, Roth  A, Niemann  S, Rothgänger  J, Sammeth  M, RIDOM: comprehensive and public sequence database for identification of Mycobacterium species. BMC Infect Dis. 2003;3:26. DOIPubMed
  15. Supply  P, Allix  C, Lesjean  S, Cardoso-Oelemann  M, Rüsch-Gerdes  S, Willery  E, Proposal for standardization of optimized mycobacterial interspersed repetitive unit–variable-number tandem repeat typing of Mycobacterium tuberculosis. J Clin Microbiol. 2006;44:4498–510 . DOIPubMed

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Page created: November 19, 2013
Page updated: November 19, 2013
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