Volume 19, Number 12—December 2013
Dispatch
Novel Cause of Tuberculosis in Meerkats, South Africa
Table 2
MIRU-VNTR patterns of Mycobacterium suricattae and representative isolates of selected members of the M. tuberculosis complex*
Locus | MIRU-VNTR copy number |
|||
---|---|---|---|---|
M. africanum†| M. mungi†| M. suricattae | Dassie bacillus†| |
MIRU 2 | 2 | 2 | 2 | 2 |
VNTR 424/Mtub04 | 4 | 3 | 3‡, 2§ | 2 |
VNTR 577/ETR-C | 5 | 3 | 5 | 5 |
MIRU 4/ETR-D | 2 | 3 | 2 | 3 |
MIRU 40 | 2 | 1 | 2 | 2 |
MIRU 10 | 7 | 5 | 6 | 7 |
MIRU 16 | 4 | 3 | 2 | 3 |
VNTR 1955/Mtub21 | 4 | 3 | 3 | 3 |
MIRU 20 | 2 | 2 | 2 | 2 |
VNTR 2163b/QUB11b | 5 | – | – | 7 |
VNTR 2165/ETR-A | 6 | 6 | – | 6 |
VNTR2347/Mtub29 | 3 | 3 | 3 | 3 |
VNTR 2401/Mtub30 | 4 | 4 | 4‡, 5§ | 3 |
VNTR 2461/ETR-B | 4 | 4 | 5 | 4 |
MIRU 23 | 4 | 4 | 4 | 4 |
MIRU 24 | 2 | 2 | 3 | 2 |
MIRU 26 | 4 | 4 | 4 | 5 |
MIRU 27 | 3 | 3 | 1 | 4 |
VNTR 3171/Mtub 34 | 3 | 3 | 3 | 3 |
MIRU 31/ETR-E | 5 | 8 and 9 | 5 | 5 |
VNTR 3690/Mtub 39 | 4 | – | 8 | 5 |
VNTR 4052/QUB 26 | 6 | – | 3 | 4 |
VNTR 4156/QUB 4156 | 3 | – | 1 | 3 |
MIRU 39 | 2 | 2 | 2 | 2 |
*MIRU-VNTR, mycobacterial interspersed repetitive unit–variable number tandem repeats; –, no amplification.
†From Alexander et al., 2010 (4).
‡Copy number of 3 isolates from 2 meerkats, including MK172.
§Copy number of a fourth isolate from a third meerkat.
References
- Warren RM, Gey van Pittius NC, Barnard M, Hesseling A, Engelke E, de Kock M, Differentiation of Mycobacterium tuberculosis complex by PCR amplification of genomic regions of difference. Int J Tuberc Lung Dis. 2006;10:818–22 .PubMed
- Kamerbeek J, Schouls L, Kolk A, van Agterveld M, van Soolingen D, Kuijper S, Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J Clin Microbiol. 1997;35:907–14 .PubMed
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