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Volume 19, Number 12—December 2013


Antiviral Susceptibility of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Poultry, Vietnam, 2009–2011

Ha T. Nguyen, Tung Nguyen, Vasiliy P. Mishin, Katrina Sleeman, Amanda Balish, Joyce Jones, Adrian Creanga, Henju Marjuki, Timothy M. Uyeki, Dang H. Nguyen, Diep T. Nguyen, Hoa T. Do, Alexander I. Klimov, Charles T. Davis, and Larisa V. GubarevaComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (H.T. Nguyen, V.P. Mishin, K. Sleeman, A. Balish, J. Jones, H. Marjuki, T.M. Uyeki, A.I. Klimov, C.T. Davis, L.V. Gubareva); Battelle Memorial Institute, Atlanta (H.T. Nguyen, A. Creanga); National Center for Veterinary Diagnostics, Hanoi, Vietnam (T. Nguyen, D.H. Nguyen, D.T. Nguyen); Atlanta Research and Education Foundation, Atlanta (J. Jones)

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Table 4

Reduction of virus yield in MDCK-SIAT1 cells in the presence of favipiravir*

H5N1 subtype NA Mean±SD virus yield (log10TCID50/mL;), favipiravir (µmol/L)
EC90 (µmol/L), mean±SD
0 0.4 1.6 6.3 25 100
A/dk/VN/NCVD-680/2011 wildtype 6.9 ± 0.6 6.9 ± 0.5 5.7 ± 0.7 6.3 ± 0.4 3.8 ± 0.9 3.2 ± 2.4
A/dk/VN/NCVD-664/2010 H275Y 7.6 ± 0.5 6.9 ± 0.8 7.5 ± 0.5 6.9 ± 0.7 5.4 ± 0.8 5.9 ± 3.2

*Multiplicity of infection 0.0001/cell in 24-well plate; TCID50/mL, 50% tissue culture infectious dose; EC90, 90% effective concentration; NA, neuraminidase.
†Below the limit of detection, 1.4 log10/mL.

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