Volume 19, Number 12—December 2013
Research
Antiviral Susceptibility of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Poultry, Vietnam, 2009–2011
Table 4
Reduction of virus yield in MDCK-SIAT1 cells in the presence of favipiravir*
H5N1 subtype | NA | Mean±SD virus yield (log10TCID50/mL;), favipiravir (µmol/L) |
EC90 (µmol/L), mean±SD | |||||
---|---|---|---|---|---|---|---|---|
0 | 0.4 | 1.6 | 6.3 | 25 | 100 | |||
A/dk/VN/NCVD-680/2011 | wildtype | 6.9 ± 0.6 | 6.9 ± 0.5 | 5.7 ± 0.7 | 6.3 ± 0.4 | 3.8 ± 0.9 | † | 3.2 ± 2.4 |
A/dk/VN/NCVD-664/2010 | H275Y | 7.6 ± 0.5 | 6.9 ± 0.8 | 7.5 ± 0.5 | 6.9 ± 0.7 | 5.4 ± 0.8 | † | 5.9 ± 3.2 |
*Multiplicity of infection 0.0001/cell in 24-well plate; TCID50/mL, 50% tissue culture infectious dose; EC90, 90% effective concentration; NA, neuraminidase.
†Below the limit of detection, 1.4 log10/mL.
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