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Volume 19, Number 3—March 2013


Emergence and Spread of Extensively and Totally Drug-Resistant Tuberculosis, South Africa

Marisa Klopper, Robin Mark WarrenComments to Author , Cindy Hayes, Nicolaas Claudius Gey van Pittius, Elizabeth Maria Streicher, Borna Müller, Frederick Adriaan Sirgel, Mamisa Chabula-Nxiweni, Ebrahim Hoosain, Gerrit Coetzee, Paul David van Helden, Thomas Calldo Victor, and André Phillip Trollip
Author affiliations: Author affiliations: Stellenbosch University, Cape Town, South Africa (M. Klopper, R.M. Warren, N.C. Gey van Pittius, E.M. Streicher, B. Müller, F.A. Sirgel, P.D. van Helden, T.C. Victor, AP.. Trollip); National Health Laboratory Services, Port Elizabeth, South Africa (C. Hayes, G. Coetzee); Swiss Tropical and Public Health Institute, Basel, Switzerland (B. Müller); University of Basel, Basel (B. Müller); Nelson Mandela Metropolitan Municipality, Port Elizabeth (M. Chabula-Nxiweni); Human Sciences Research Council, Port Elizabeth (E. Hoosain)

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Table 2

Correlation of culture-based and molecular-based drug-susceptibility testing among atypical Beijing isolates, South Africa, 2008–2009*

Drug/gene CB-DST R, MB-DST R CB-DST S, MB-DST S CB-DST R, MB-DST S CB-DST S, MB-DST R Total Correlation, %
INH/katG 217 9 1 0 227 99.6
RIF/rpoB 219 9 0 0 228 100
STR/rrs500 191 6 2 16 215 91.6
EMB/embB 56 5 2 152 215 28.4
ETH/inhA promoter 76 25 5 86 192 52.6
OFL/gyrA 78 93 0 29 200 85.5
AMK/rrs1400 167 32 7 9 215 92.6
CAP/rrs1400 21 38 1 155 215 27.4

*CB-DST, culture-based drug susceptibility testing; R, resistant; MB-DST, molecular-based DST; S, sensitive; INH, isoniazid; RIF, rifampin; STR, streptomycin; EMB, ethambutol; ETH, ethionamide; OFL, ofloxacin; AMK, amikacin; CAP, capreomycin.

Main Article