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Volume 19, Number 4—April 2013
Research

Transmission of Hepatitis E Virus from Rabbits to Cynomolgus Macaques

Peng Liu, Qiu-Ning Bu, Ling WangComments to Author , Jian Han, Ren-Jie Du, Ya-Xin Lei, Yu-Qing Ouyang, Jie Li, Yong-Hong Zhu, Feng-Min Lu, and Hui Zhuang
Author affiliations: Peking University Health Science Center, Beijing, People’s Republic of China

Main Article

Table

Comparison of the complete genome sequence of rabbit HEV passed in macaques with that of the inoculum*

Nucleotide position† Genomic region Nucleotide
 Amino acid
CHN-BJ-R14‡ rHEV-Cy1§ Position† Substitution
614 ORF1-MeT C T 197 Silent
957 ORF1-Y T C 311 Thr to Ile
1667 ORF1-PCP T C 548 Silent
1875 ORF1 T C 617 Pro to Leu
2706 ORF1-X G A 894 Asp to Gly
3553 ORF1-Hel A T 1176 Silent
3571 ORF1-Hel C T 1182 Silent
3859 ORF1-RdRp C A 1278 Silent
3889 ORF1-RdRp C T 1288 Silent
3972 ORF1-RdRp G A 1316 Glu to Gly
4215 ORF1-RdRp C T 1397 Leu to Pro
4285 ORF1-RdRp A G 1420 Silent
4414 ORF1-RdRp T C 1463 Silent
4427 ORF1-RdRp C T 1468 Tyr to His
4882 ORF1-RdRp T C 1619 Silent
5028 ORF1-RdRp T C 1668 Ala to Val
5531 ORF2 C T 100 Silent
ORF3 104 Ala to Val
5713 ORF2 T A 161 Ile to Asn

*HEV, hepatitis E virus; ORF, open reading frame; Thr, Threonine; Ile, Isoleucine; Pro, proline; Leu, leucine; Asp, aspartic acid; Gly, glycine; Glu, glutamic acid; Tyr, tyrosine; His, histidine; Ala, alanine; Val, valine; Asn, asparagine.
†Nucleotide or amino acid position according to the rabbit HEV CHN-BJ-R14 strain.
‡CHN-BJ-R14, HEV isolate recovered from the rabbit HEV inoculum in this study.
§rHEV-Cy1, HEV isolate recovered from the fecal sample of 1 monkey at 3 wpi in this study.
¶Putative domains in ORF1. MeT, methyltransferase domain; Y, Y domain; PCP, papain-like cysteine protease domain; X, X or macro domain; Hel, helicase domain; RdRp, RNA-dependent RNA polymerase domain.

Main Article

1These authors contributed equally to this article.

Page created: March 13, 2013
Page updated: March 13, 2013
Page reviewed: March 13, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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