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Volume 19, Number 6—June 2013
Synopsis

Zoonotic Mycobacterium bovis–induced Tuberculosis in Humans

Borna MüllerComments to Author , Salome Dürr, Silvia Alonso, Jan Hattendorf, Cláudio J.M. Laisse, Sven D.C. Parsons, Paul D. van Helden, and Jakob Zinsstag
Author affiliations: Stellenbosch University, Cape Town, South Africa (B. Müller, S.D.C. Parsons, P.D. van Helden); Swiss Tropical and Public Health Institute, Basel, Switzerland (B. Müller, J. Hattendorf, J. Zinsstag); University of Basel, Basel (B. Müller, J. Hattendorf, J. Zinsstag); University of Berne, Berne, Switzerland (S. Dürr); Royal Veterinary College, Hertfordshire, UK (S. Alonso); Veterinary Faculty, Eduardo Mondlane University, Maputo, Mozambique (C. J. M. Laisse)

Main Article

Table 2

Overview of selected reports from Africa on zoonotic Mycobacterium bovis–induced TB in humans*

ID Country Setting Sampling Detection Years M. bovis TB‡ 95% CI Location
1131 Tanzania NA Conv. Mol. NA 20 53 37.7 24.8–52.1 EPTB
1131 Tanzania Arusha region Conv. Mol. 1994 4 11 36.4 10.9–69.2 EPTB
1074 Ethiopia Butajira health center, southeastern Ethiopia System. Mol. 2000/2001 11 35 31.4 16.9–49.3 EPTB
1074 Ethiopia NA Conv. Biochem. NA 14 48 29.2 17.0–44.1 PTB
15 Ethiopia Felegehiwot hospital Conv. Biochem. 2007/2008 8 47 17.0 7.6–30.8 Both
65 Ethiopia NA Conv. Biochem. NA 7 42 16.7 7.0–31.4 Both
1074 Ethiopia Fitche Hospital TB clinic Conv. Biochem. 2004/2005 7 42 16.7 7.0–31.4 Both
294 Tanzania Arusha region and Southern Highlands Surv. Biochem. 1993–1996 7 44 15.9 6.6–30.1 Both
73 Nigeria Jos Conv. Biochem. NA 10 65 15.4 7.6–26.5 PTB
68 Uganda Karamojo region Conv. Mol. NA 3 24 12.5 2.7–32.4 EPTB
159 Tanzania Three districts in Arusha region Surv. Biochem. 1999–2001 7 65 10.8 4.4–20.9 EPTB
459 Malawi Blantyre, Queen Elizabeth Central Hospital Conv. Biochem. NA 1 30 3.3 0.1–17.2 PTB
62 Ghana Korle-Bu Teaching Hospital Conv. Biochem. 2003 2 64 3.1 0.4–10.8 PTB
464 Madagascar Institut d'Hygiène Sociale, Antananarivo Conv. Mol. 1994 3 126 2.4 0.5–6.8 PTB
340 Madagascar Antananarivo Surv. Other 1994/1995 2 156 1.3 0.2–4.6 EPTB
292 Madagascar Antananarivo, Antsirabe, Fianarantsoa, and Mahajanga Rand. Mol. 1994/1995 4 316 1.3 0.3–3.2 PTB
243 Uganda Kampala Conv. Biochem. 1995–1997 1 234 0.4 0.0–2.4 PTB
52 Uganda Kampala, Rubaga division Surv. Mol. 2006 1 386 0.3 0.0–1.4 PTB
222 Cameroon Ouest Province Surv. Mol. 1997/1998 1 455 0.2 0.0–1.2 PTB
80 Burkina Faso Health centers in Ouagadougou and Bobo Dioulasso Conv. Mol. 2001 0 120 0.0 0.0–3.0¶ PTB
12 Burundi Bujumbara, Bubanza Hospital Conv. Mol. 1987–1994 0 117 0.0 0.0–3.1¶ Both
165 Chad Chari-Baguirmi Conv. Mol. 2002 0 10 0.0 0.0–30.8¶ Both
12 Côte d'Ivoire TB and rural health centers in Côte d’Ivoire Cluster Mol. 1994–1996 0 320 0.0 0.0–1.1¶ PTB
464 Madagascar Antananarivo prison Conv. Mol. 1994 0 36 0.0 0.0–9.7¶ PTB
12 Sierra Leone Western Area and Kenema districts Surv. Mol. 2003/2004 0 97 0.0 0.0–3.7¶ PTB
32 Uganda Mbarara district Rand. Mol. 2004/2005 0 70 0.0 0.0–5.1¶ Both

*TB, tuberculosis; ID, record identification number (Technical Appendix 2); NA, not available; Conv., convenience sample/not specified; Mol., molecular-based detection method; EPTB, extrapulmonary TB; System, systematic sampling; Biochem, biochemical detection method; PTB, pulmonary TB; Surv.,surveillance data; Rand., random sampling; Cluster, cluster sampling.
†Number of putative zoonotic cases of Mycobacterium bovis.
‡Total number of bacteriologically confirmed and characterized TB cases.
§%, proportion of zoonotic TB among all TB cases.
¶One-sided 97.5% CIs are indicated.

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Page created: May 21, 2013
Page updated: May 21, 2013
Page reviewed: May 21, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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