Volume 19, Number 6—June 2013
Synopsis
New Delhi Metallo-β-Lactamase–producing Enterobacteriaceae, United States
J. Kamile Rasheed
, Brandon Kitchel, Wenming Zhu, Karen F. Anderson, Nancye C. Clark, Mary Jane Ferraro, Patrice Savard, Romney M. Humphries, Alexander J. Kallen, and Brandi M. Limbago
, Brandon Kitchel, Wenming Zhu, Karen F. Anderson, Nancye C. Clark, Mary Jane Ferraro, Patrice Savard, Romney M. Humphries, Alexander J. Kallen, and Brandi M. Limbago
Table 3
Antimicrobial drug susceptibility profiles of NDM-producing isolates collected and Escherichia coli transformants, United States, April 2009–March 2011*
| Isolate no. | Organism | MIC, µg/mL |
Broth microdilution MBL screen result |
Modified Hodge test result |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TGC | SXT | CTX | FEP | ATM | DOR | ETP | MER | IMP | IMP+EP† | Ratio | MBL | ETP/MER | ||||
| 0S-506 | Klebsiella pneumoniae | ≤0.5 | >8 | >64 | >32 | >64 | >8 | >4 | >8 | >32 | 1 | ≥64 | + | –/– | ||
| 1100770 | K. pneumoniae | 2 | >8 | >64 | >32 | >64 | >8 | >4 | >8 | 32 | 0.5 | 64 | + | +/– | ||
| 1100975 | K. pneumoniae | 2 | >8 | >64 | >32 | >64 | >8 | >4 | >8 | 32 | 1 | 32 | + | +/+ | ||
| 1100192 | K. pneumoniae | 1 | >8 | >64 | >32 | >64 | >8 | >4 | >8 | 8 | ≤0.5 | ≥16 | + | +/– | ||
| 1000527 | K. pneumoniae | >4 | >8 | >64 | >32 | >64 | >8 | >4 | >8 | >32 | ≤0.5 | >64 | + | +/+ | ||
| 1101459 |
K. pneumoniae |
2 |
>8 |
>64 |
>32 |
>64 |
>8 |
>4 |
8 |
16 |
≤0.5 |
≥32 |
+ |
+/+ |
||
| 1101168 |
Salmonella enterica serovar Senftenberg |
1 |
0.5 |
>64 |
>32 |
>64 |
8 |
>4 |
8 |
4 |
≤0.5 |
≥8 |
+ |
+/+ |
||
| 1100101 | E. coli | ≤0.5 | >8 | >64 | >32 | >64 | >8 | >4 | >8 | 16 | 1 | 16 | + | +/– | ||
| 1001728 |
E. coli |
≤0.5 |
>8 |
>64 |
>32 |
16 |
>8 |
>4 |
>8 |
8 |
≤0.5 |
≥16 |
+ |
+/+ |
||
| 1000654 |
Enterobacter cloacae |
>4 |
>8 |
>64 |
>32 |
>64 |
>8 |
>4 |
>8 |
>32 |
4 |
>8 |
+ |
+/+ |
||
| 0S-506 | TF | ≤0.5 | ≤0.25 | >64 | 16 | 64 | 4 | 4 | 4 | 4 | ≤0.5 | ≥8 | + | +/+ | ||
| 1100770 | TF | ≤0.5 | ≤0.25 | >64 | 32 | 32 | 4 | 8 | 4 | 4 | ≤0.5 | ≥8 | + | +/– | ||
| 1100975 | TF | ≤0.5 | ≤0.25 | >64 | 16 | 32 | 4 | 4 | 4 | 2 | ≤0.5 | ≥4 | + | +/– | ||
| 1100192 | TF | ≤0.5 | ≤0.25 | >64 | 16 | ≤2 | 2 | 2 | 1 | 2 | ≤0.5 | ≥4 | + | +/+ | ||
| 1000527 | TF | ≤0.5 | ≤0.25 | >64 | 32 | 8 | 8 | 8 | 8 | 4 | ≤0.5 | ≥8 | + | +/+ | ||
| 1101459 | TF | ≤0.5 | ≤0.25 | >64 | 16 | ≤2 | 4 | 4 | 4 | 4 | ≤0.5 | ≥8 | + | +/+ | ||
| 1101168 | TF | ≤0.5 | ≤0.25 | >64 | 16 | ≤2 | 8 | >8 | 8 | 8 | ≤0.5 | ≥16 | + | +/+ | ||
| 1100101 | TF | ≤0.5 | ≤0.25 | >64 | >32 | >64 | >8 | >8 | 16 | 8 | ≤0.5 | ≥16 | + | +/+ | ||
| 1001728 | TF | ≤0.5 | ≤0.25 | >64 | 32 | 32 | 8 | 8 | 8 | 8 | ≤0.5 | ≥16 | + | –/+ | ||
| 1000654 |
TF |
≤0.5 |
>8 |
>64 |
>32 |
>64 |
>8 |
>8 |
32 |
32 |
≤0.5 |
≥64 |
+ |
+/+ |
||
| Recipient | E. coli DH-10BT1 | ≤0.5 | ≤0.25 | ≤0.12 | ≤0.5 | ≤2 | ≤0.12 | ≤0.12 | ≤0.12 | ≤0.5 | ≤0.5 | ≤1 | – | –/– | ||
*NDM, New Delhi metallo-β-lactamase; ID, identification; MBL, Ambler class B metallo-β-lactamase; TGC, tigecycline; SXT, trimethoprim/sulfamethoxazole; CTX, cefotaxime; FEP, cefepime; ATM, aztreonam; DOR, doripenem; ETP, ertapenem; MER, meropenem; IMP, imipenem; EP, chelator; TF, transformant.
†IMP + EDTA + 1,10-phenanthroline, μg/mL.
Page created: May 20, 2013
Page updated: May 20, 2013
Page reviewed: May 20, 2013
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