Volume 19, Number 7—July 2013
Research
Mutation in Spike Protein Cleavage Site and Pathogenesis of Feline Coronavirus
Beth N. Licitra1, Jean K. Millet1, Andrew D. Regan, Brian S. Hamilton, Vera D. Rinaldi, Gerald E. Duhamel, and Gary R. Whittaker
Table 2
Sequence of FCoV spike at S1/S2 junction in cats sampled for feline coronavirus*
| Time | Cat 234 | Cat 304 |
|---|---|---|
| t = 1 | NHTHTRRSRR↓SAPVAV | NHTHTRRSRR↓SAPVAV |
| t = 2 | NHTHTRRSLR↓SAPVAV | NHTHTRRARR↓SAPVAV |
*Underlines indicate nucleotide substitution. FCoV, feline coronavirus; S1/S2, cleavage site of spike protein; t = 1, both cats disease-free; ↓ , cleavage site; t = 2, cat 234 feline infectious peritonitis–positive, cat 304 disease-free.
1These authors contributed equally to this article.
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