Volume 19, Number 7—July 2013
Research
Mutation in Spike Protein Cleavage Site and Pathogenesis of Feline Coronavirus
Table 2
Sequence of FCoV spike at S1/S2 junction in cats sampled for feline coronavirus*
Time | Cat 234 | Cat 304 |
---|---|---|
t = 1 | NHTHTRRSRR↓SAPVAV | NHTHTRRSRR↓SAPVAV |
t = 2 | NHTHTRRSLR↓SAPVAV | NHTHTRRARR↓SAPVAV |
*Underlines indicate nucleotide substitution. FCoV, feline coronavirus; S1/S2, cleavage site of spike protein; t = 1, both cats disease-free; ↓ , cleavage site; t = 2, cat 234 feline infectious peritonitis–positive, cat 304 disease-free.
1These authors contributed equally to this article.