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Volume 20, Number 1—January 2014
Research

Progenitor “Mycobacterium canettii” Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti

Yann Blouin, Géraldine Cazajous, Céline Dehan, Charles Soler, Rithy Vong, Mohamed Osman Hassan, Yolande Hauck, Christian Boulais, Dina Andriamanantena, Christophe Martinaud, Émilie Martin, Christine Pourcel, and Gilles VergnaudComments to Author 
Author affiliations: Université Paris-Sud, Orsay, France (Y. Blouin, Y. Hauck, C. Pourcel, G. Vergnaud); Centre National de la Recherche Scientifique, Orsay (Y. Blouin, Y. Hauck, C. Pourcel, G. Vergnaud); Hôpital Militaire Bouffard, Djibouti, Republic of Djibouti (G. Cazajous, C. Dehan, C. Boulais); Hôpital d'Instruction des Armées Percy, Clamart, France (C. Soler, R. Vong, C. Martinaud); Hôpital Paul Faure, Djibouti (M. Osman Hassan); Hôpital d'Instruction des Armées Bégin, Saint-Mandé, France (D. Andriamanantena); Centre Hospitalier Lyon Sud, Lyon, France (E. Martin); Institut de Recherche Biomédicale des Armées, Brétigny, France (G. Vergnaud)

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Figure 2

Early evolution of Mycobacterium tuberculosis was deciphered using clone A sequence data. A minimum spanning tree was drawn after removal of polymorphisms occurring in clusters, indicative of horizontal gene transfer events. The approximate position of the branching point of Percy302 (STB-K) the most distantly related M. canettii strain (5) is indicated by the blue star. The red star is the position of the most recent common ancestor of M. tuberculosis. The branch lengths of only the most intern

Figure 2. . Early evolution of Mycobacterium tuberculosis was deciphered using clone A sequence data. A minimum spanning tree was drawn after removal of polymorphisms occurring in clusters, indicative of horizontal gene transfer events. The approximate position of the branching point of Percy302 (STB-K) the most distantly related M. canettii strain (5) is indicated by the blue star. The red star is the position of the most recent common ancestor of M. tuberculosis. The branch lengths of only the most internal branches are indicated. Branch length values inside clone A are <3. The position of the reference strain H37Rv is indicated. Four hundred seventy-one polymorphisms separate the red star from H37Rv. A logarithmic branch length representation was used.

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