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Volume 20, Number 10—October 2014
Research

Effects of Mefloquine Use on Plasmodium vivax Multidrug Resistance

Nimol Khim, Voahangy Andrianaranjaka, Jean Popovici, Saorin Kim, Arsene Ratsimbasoa, Christophe Benedet, Celine Barnadas, Remy Durand, Marc Thellier, Eric Legrand, Lise Musset, Michela Menegon, Carlo Severini, Bakri Y.M. Nour, Magali Tichit, Christiane Bouchier, Odile Mercereau-Puijalon, and Didier MénardComments to Author 
Author affiliations: Institut Pasteur, Phnom Penh, Cambodia (N. Khim, J. Popovici, S. Kim, C. Benedet, D. Ménard); Institut Pasteur, Antananarivo, Madagascar (V. Andrianaranjaka); Université d’Antananarivo, Antananarivo (A. Ratsimbasoa); Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia (C. Barnadas); University of Melbourne, Melbourne (C. Barnadas); Hôpital Avicenne, Bobigny, France (R. Durand); Centre Hospitalier Universitaire Pitié Salpetrière, Paris, France (M. Thellier); Institut Pasteur, Cayenne, French Guiana (E. Legrand, L. Musset); Istituto Superiore di Sanità (ISS), Rome, Italy (M. Menegon, C. Severini); University of Gezira, Wad Medani, Sudan (B.Y.M. Nour); Institut Pasteur, Paris (M. Tichit, C. Bouchier, O. Mercereau-Puijalon)

Main Article

Table 2

Variation in number of copies of Plasmodium vivax mdr-1 gene among isolates from residents of malaria-endemic continents and from travelers from France to those areas, 1997–2010

Continent Residents Travelers Total p value
South America
Isolates with >1 Pvmdr-1 copy 117 41 158
No. (%; 95% CI) 69 (59; 50–68) 14 (34; 20–51) 83 (53; 44–60) 0.01*
Range 1–5 1–2 1–5
Copies, no. (%)
1 48 (41) 27 (66) 75 (47) 10–4*
2 26 (22) 14 (34) 40 (25)
3 32 (27) 0 32 (20)
4 9 (8) 0 9 (6)
5 2 (2) 0 2 (1)
Mean (95% CI)
 2.0 (1.8–2.2)
 1.2 (1.0–1.3)
 1.8 (1.7–2.0)
 <10–5†
Asia
Isolates with >1 Pvmdr-1 copy 117 60 177
No. (%; 95% CI) 37 (32; 23–45) 23 (38; 24–57) 60 (34; 26–44) 0.5*
Range 1–4 1–3 1–4
Copies, no. (%)
1 80 (68) 37 (62) 117 (66) 0.68*
2 34 (29) 22 (37) 56 (32)
3 2 (2) 1 (2) 3 (2)
4 1 (1) 0 1 (1)
Mean (95% CI)
 1.3 (1.2–1.4)
 1.4 (1.3–1.5)
 1.3 (1.2–1.4)
 0.41†
Africa
Isolates with >1 Pvmdr-1 copy 258 14 272
No. (%; 95% CI) 3 (1; 0.2–3) 8 (57; 24–100) 11 (4; 2–7) <10–8*
Range 1–2 1–2 1–2
Copies, no. (%)
1 255 (99) 6 (43) 261 (96) <10–8*
2 3 (1) 8 (57) 11 (4)
Mean (95% CI) 0.9 (0.9–1.0) 1.3 (1.1–1.6) 0.9 (0.9–1.0) <10–8†

*χ2 test.
†1-Way analysis of variance.

Main Article

Page created: September 12, 2014
Page updated: September 12, 2014
Page reviewed: September 12, 2014
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