Figure 3. Biomarkers associated with age-dependent hemorrhagic manifestations (heme) for patients with Ebola virus disease: black, adult heme; white, adult nonheme; dark gray, pediatric heme; light gray, pediatric nonheme. A) Serum amyloid antigen; B) plasminogen activator inhibitor 1. Mean levels are depicted in each patient group as a function of time after symptom onset. Error bars represent SE; * indicates p<0.05. Numbers of specimens included in each group are as follows: adult heme at 0–5 days, 9; adult non-heme at 0–5 days, 38; adult heme at 6–10 days, 12; adult non-heme at 6–10 days, 34; adult heme at 11–15 days, 9; adult non-heme at 11–15 days, 10; pediatric heme at 0–5 days, 7; pediatric non-heme at 0–5 days, 18; pediatric heme at 6–10 days, 6; pediatric non-heme at 6–10 days, 12; pediatric heme at 11–15 days, 2; pediatric non-heme at 11–15 days, 4.