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Volume 20, Number 10—October 2014
Dispatch

Human Infection with Highly Pathogenic A(H7N7) Avian Influenza Virus, Italy, 2013

Simona PuzelliComments to Author , Giada Rossini, Marzia Facchini, Gabriele Vaccari, Livia Di Trani, Angela Di Martino, Paolo Gaibani, Caterina Vocale, Giovanni Cattoli, Michael Bennett, John W. McCauley, Giovanni Rezza, Maria Luisa Moro, Roberto Rangoni, Alba Carola Finarelli, Maria Paola Landini, Maria Rita Castrucci, Isabella Donatelli, and the Influenza Task Force
Author affiliations: Istituto Superiore di Sanità, Rome, Italy (S. Puzelli, M. Facchini, G. Vaccari, L. Di Trani, A. Di Martino, G. Rezza, M.R. Castrucci, I. Donatelli); St. Orsola University Hospital, Bologna, Italy (G. Rossini, P. Gaibani, C. Vocale, M.P. Landini); Istituto Zooprofilattico delle Venezie, Padua, Italy (G. Cattoli); Medical Research Council National Institute for Medical Research, London, UK (M. Bennett, J.W. McCauley); Emilia-Romagna Region, Bologna (M.L. Moro, R. Rangoni, A.C. Finarelli)

Main Article

Table 1

Comparison of the nucleotide sequences of highly pathogenic avian influenza A(H7N7) virus isolate from chickens and humans, Italy, August–September 2013*

Virus, location (date)† PB2
PB1
PA
HA
NP
NA
M
232‡ 279 333 1044 183‡ 1882 2133 1251 471 1018‡ 1410 72 515‡ 541‡ 1040‡ 1347 818‡ 884‡
Chicken
A/CK/4527,
Ostellato
(Aug 13)§ C T T C C C C G A G G G A T C A A G
A/CK/4541,
Ostellato 
(Aug 13) T T G A A G
A/CK/4603,
Mordano
(Aug 19) T T A G G
A/CK/4678,
Portom 
(Aug 21) T T T A A G G
A/CK/4774,
Mordano
(Aug 27) T C T T A A
A/CK/5091,
Bondeno
(Sep 2) T C T T T A A G G A
A/CK/5051,
Mordano 
(Sep 3)
T






T

A








A





Human¶
1, Mordano
(Aug 29) T T A G
2, Mordano
(Sep 2) T T A
3, Mordano
/Ostellato
(Sep 7) T T A G# A A#

*Dots indicate no nucleotide changes; –, notavailable. HA, hemagglutinin; NA, neuraminidase; NP, nucleocapsid protein; M, matrix; PA, polymerase acidic; PB, polymerase basic; Portom, Portomaggiore.
†Date indicates date collected. A/CK/4527, A/chicken/Italy/13VIR4527–11/2013; A/CK/4541, A/chicken/Italy/13VIR4541–34/2013; A/CK/4603, A/chicken/Italy/13VIR4603/2013; A/CK/4678, A/chicken/Italy/13VIR4678–1/2013; A/CK/4774, A/chicken/Italy/13VIR4774/2013; A/CK/5091, A/chicken/Italy/13VIR5091–1/2013; A/CK/5051, A/chicken/Italy/13VIR5051–3/2013.
‡Nonsynonymous substitution.
§First isolate from chicken (index case).
¶Clinical samples.
#Nucleotide changes found only in the specimen from patient 3 and responsible for the D172G and P347Q amino acid changes.

Main Article

1Influenza Task Force members: Laura Calzoletti, Concetta Fabiani, Monica Meola, Annapina Palmieri, Arianna Boni, Guendalina Zaccaria (Istituto Superiore di Sanità, Rome); Marisa Cova, Valerio Parmeggiani, Claudio Po, Roberto Cagarelli, Gabriele Squintani, Emanuela Bedeschi (Emilia-Romagna Region, Bologna); and Maria Grazia Pompa (Ministry of Health, Rome).

Page created: September 22, 2014
Page updated: September 22, 2014
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