Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 20, Number 11—November 2014
Research

Drug-Resistant Candida glabrata Infection in Cancer Patients

Dimitrios Farmakiotis1, Jeffrey J. Tarrand, and Dimitrios P. KontoyiannisComments to Author 
Author affiliations: The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (D. Farmakiotis, J.J. Tarrand, D.P. Kontoyiannis); Baylor College of Medicine, Houston (D. Farmakiotis)

Main Article

Table 3

Factors present at the time of candidemia and associated with caspofungin resistance in cancer patients with Candida glabrata fungemia, MD Anderson Cancer Center, Houston, Texas, USA, March 2005–September 2013*

Factor No. (%)
p value Multivariate analysis
Susceptible
(n = 107) Intermediate
 (n = 24) Resistant
(n = 15) Odds ratio (95% CI) p value
Hematologic malignancy 27 (25.23) 12 (50) 8 (53.33) .012
Leukemia 12 (11.21) 4 (16.66) 6 (40) .012
Hematopoetic stem cell transplantation 6 (5.61) 5 (20.83) 5 (33.33) .013
Neutropenia (<500 cells/μL) 16 (14.95) 6 (25) 6 (40) .016
Lymphopenia (<500 cells/μL) 59 (55.14) 15 (62.5) 12 (80) .069
Monocytopenia (<100 cells/μL) 20 (18.69) 10 (41.66) 9 (60) <0.001 3.53 (1.44–8.65) .006
Mechanical ventilation 17 (15.89) 3 (12.5) 7 (46.66) .024
Any corticosteroids† 56 (52.33) 17 (70.83) 12 (80) .004
Total parenteral nutrition 22 (20.56) 5 (20.83) 9 (60) .005 3.37 (1.37–8.24) .008
Echinocandin exposure† 15 (14.02) 6 (25) 11 (73.33) <0.001 2.75 (1.09–6.95) .032
Fluconazole resistance 15 (14.02) 6 (25) 9 (60) <0.001 3.16 (1.13–7.88) .013

Main Article

1Current affiliation: Harvard Medical School Brigham and Women’s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA

Page created: October 15, 2014
Page updated: October 15, 2014
Page reviewed: October 15, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external