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Volume 20, Number 11—November 2014
Dispatch

Global Incidence of Carbapenemase-Producing Escherichia coli ST131

Gisele Peirano, Patricia Bradford, Krystyna M. Kazmierczak, Robert E. Badal, Meredith Hackel, Daryl J. Hoban, and Johann D.D. PitoutComments to Author 
Author affiliations: University of Calgary Faculty of Medicine, Calgary, Alberta, Canada (G. Peirano, J.D.D. Pitout); AstraZeneca Pharmaceuticals LP, Waltham, Massachusetts, USA (P.A. Bradford); International Health Management Associates, Schaumburg, Illinois, USA (K.M. Kazmierczak, R.E. Badal, M. Hackel, D.J. Hoban)

Main Article

Table 1

Antimicrobial drug susceptibilities, β-lactamase types, fimH30 lineage, and different virotypes of Escherichia coli that have carbapenemases*

Characteristic No. (%) non-ST131,n = 75 No. (%) ST131, n = 41 Total no. (%),
n=116 p value
Antimicrobial drug nonsusceptible
Ampicillin-sulbactam 75 (100) 41 (100) 116 (100) 1
Piperacillin-tazobactam 75 (100) 41 (100) 116 (100) 1
Ceftriaxone 65 (87) 39 (95) 104 (90) 0.5
Ceftazidime 65 (87) 39 (95) 104 (90) 0.5
Cefepime 65 (87) 39 (95) 104 (90) 0.5
Cefoxitin 65 (87) 39 (95) 104 (90) 0.5
Ertapenem 68 (91) 40 (98) 108 (93) 0.4
Imipenem 71 (95) 40 (98) 111 (96) 1
Amikacin 29 (39) 16 (39) 45 (39) 1
Ciprofloxacin 46 (61) 40 (95) 86 (74) <0.001
Tigecycline 2 (3) 1 (2) 3 (3) NA
Colistin
 0
 0
 0
 NA
Type of β-lactamase
NDM 41 (55) 3 (7) 44 (38) <0.001
KPC 14 (19) 24 (59) 38 (32) <0.001
OXA-48-like 17 (23) 13 (32) 30 (26) 0.2
VIM 2 (3) 0 2 (2) NA
IMP 1 (1) 1 (2) 2 (2) NA
CTX-M-15 39 (52) 15 (37) 54 (47) 0.1
H30 lineage
35 (47)
 24 (58)
 59 (51)
 0.3
Virotype
A 1 (1) 0 1 NA
B 8 (11) 0 8 NA
C 9 (12) 39 (95) 48 (41) <0.001
D 4 (5) 2 (5) 6 (5) NA
ND 53 (71) 0 53 (46) NA

*Nonsusceptible, either intermediate or resistant; NA, not available (too many cells numbering <5); ND: not detected; analysis was done using Stata version 10.0 (Stata Corp, College Station, TX, USA). χ2 and Fisher exact tests were used to compare group categorical data; NDM, New Delhi metallo-β-lactamase-1; KPC, Klebsiella pneumoniae carbapenemase; OXA, oxacillinase; VIM, Verona integron–encoded metallo-β-lactamase; IMP, imipenemase.

Main Article

CrossRef reports the first page should be "e00377-13" not "e00377" in reference 15 "Price, Johnson, Aziz, Clabots, Johnston, Tchesnokova, et al., 2013".

Please verify the page numbers (e00377-13) (in reference 15 "Price, Johnson, Aziz, Clabots, Johnston, Tchesnokova, et al., 2013").

PRODUCTION NOTE: This table is online only.

Page created: October 17, 2014
Page updated: October 17, 2014
Page reviewed: October 17, 2014
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