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Volume 20, Number 3—March 2014
Research

Minimal Diversity of Drug-Resistant Mycobacterium tuberculosis Strains, South Africa1

Neel R. GandhiComments to Author , James C.M. Brust, Prashini Moodley, Darren Weissman, Moonseong Heo, Yuming Ning, Anthony P. Moll, Gerald H. Friedland, A. Willem Sturm, and N. Sarita Shah
Author affiliations: Albert Einstein College of Medicine, Bronx, New York, USA (N.R. Gandhi, J.C.M. Brust, D. Weissman, M. Heo, Y. Ning, N.S. Shah); Rollins School of Public Health, Emory University, Atlanta, Georgia, USA (N.R. Gandhi); Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa (P. Moodley, A.W. Sturm); Philanjalo, Tugela Ferry, South Africa (A.P. Moll); Church of Scotland Hospital, Tugela Ferry (A.P. Moll); Yale University School of Medicine, New Haven, Connecticut, USA (G.H. Friedland)

Main Article

Table 3

Association of clinical factors and TB genotype with mortality based on Cox proportional hazards analysis, Tugela Ferry, KwaZulu-Natal Province, South Africa, 2005–2006*†

Category Unadjusted hazard ratio p value Adjusted hazard ratio p value
Spoligotype (ST) pattern Ref Ref –
ST60 (KZN) 2.78 <0.0001 0.14 0.60
ST34 (Québec) 2.48 0.002 0.65 0.07
ST1 (Beijing) 0.66 0.26 0.72 0.42
All other ST types
 Ref
Ref
DST group: drug-susceptible Ref Ref
MDR 3.37 <0.0001 3.33 <0.0001
XDR
 5.78
 <0.0001
 4.68
 <0.0001
Positive sputum smear 1.32 0.20
Extrapulmonary TB
1.67
 0.02
CD4 count
<50 cells/mm3 2.46 0.007
51–200 cells/mm3 1.41 0.30
>200 cells/mm3
 Ref
Ref
 –
Recent hospitalization 2.81 <0.0001

*Ref, referent; KZN, KwaZulu-Natal DST; drug susceptibility testing; MDR, multidrug-resistant, XDR, extensively drug resistant.
†If a patient had differing isolates on the same day, the less resistant of the 2 was used for these analyses. Results did not change when the more resistant isolate was used (data not shown).

Main Article

1Preliminary results from this study were presented at the American Thoracic Society International Conference, May 15–20, 2009, San Diego, California, USA.

Page created: February 19, 2014
Page updated: February 19, 2014
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