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Volume 20, Number 3—March 2014
Research

Minimal Diversity of Drug-Resistant Mycobacterium tuberculosis Strains, South Africa1

Neel R. GandhiComments to Author , James C.M. Brust, Prashini Moodley, Darren Weissman, Moonseong Heo, Yuming Ning, Anthony P. Moll, Gerald H. Friedland, A. Willem Sturm, and N. Sarita Shah
Author affiliations: Albert Einstein College of Medicine, Bronx, New York, USA (N.R. Gandhi, J.C.M. Brust, D. Weissman, M. Heo, Y. Ning, N.S. Shah); Rollins School of Public Health, Emory University, Atlanta, Georgia, USA (N.R. Gandhi); Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa (P. Moodley, A.W. Sturm); Philanjalo, Tugela Ferry, South Africa (A.P. Moll); Church of Scotland Hospital, Tugela Ferry (A.P. Moll); Yale University School of Medicine, New Haven, Connecticut, USA (G.H. Friedland)

Main Article

Table 1

Demographic and clinical characteristics of patients with drug-susceptible, MDR TB, and XDR TB, Tugela Ferry, KwaZulu-Natal Province, South Africa 2005–2006*

Characteristic
 Drug-susceptible TB
 MDR TB
 XDR TB
Total no. 86 67 74
Female sex 31 (36) 34 (51) 38 (51)
Age, y, median (IQR)
 34 (29–42)
 34 (29–43)
 33 (29–40)
Tested for HIV 68 (85) 49 (73) 63 (79)
HIV-positive† 61 (90) 45 (92) 63 (100)
CD4 available at diagnosis 33 (54) 30 (67) 32 (51)
Median cells/mm3 (IQR) 74 (29–129) 85.5 (47–217) 94 (46.5–169)
Viral load available at diagnosis 20 (33) 11 (24) 15 (24)
Median copies/mL (IQR) 110,000 (23,000–570,000) 120,000 (2,000–200,000) 71,000 (89–530,000)
Receiving ARV therapy at diagnosis
 19 (31)
 12 (27)
 18 (29)
Sputum smear result available 80 (93) 65 (97) 72 (97)
Positive
 45 (56)
 43 (66)
 50 (69)
Presence of extrapulmonary TB
 20 (23)
 17 (25)
 22 (30)
Previous TB treatment†
Any
 29 (34)
 47 (70)
 53 (72)
Previous hospitalization†
Past 2 y 18 (21) 35 (52) 44 (59)

*N = 227; values indicate no. (%) unless otherwise noted. MDR TB, multidrug-resistant tuberculosis; XDR TB, extensively drug-resistant TB; IQR, interquartile range; ARV, antiretroviral.
†p<0.05.

Main Article

1Preliminary results from this study were presented at the American Thoracic Society International Conference, May 15–20, 2009, San Diego, California, USA.

Page created: February 19, 2014
Page updated: February 19, 2014
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