Volume 20, Number 5—May 2014
Chronic Wasting Disease Agents in Nonhuman Primates
|Disease incidence†||Inoculum‡||Route of inoculation||Titer inoculated§||Incubation days, range, (avg)¶||Weight change range, % (avg,%)|
|13/13||MD-1,2,3 Elk-1,2,3 WTD-1,2||Intracerebral||1.3 × 105-1.0 × 107||33–75 (46)||−8 to −43 (−29.5)|
|11/12#||MD-1,3 Elk-1,2,3 WTD-1,2||Oral||9.6 x 107-1.5 × 109||59–107 (68)||−8 to −41 (−28)|
|2/2||SM-CWD||Intracerebral||NA||23–24 (23.5)||−8 to −21 (−14.5)|
|0/1||Normal elk||Intracerebral||NA||82 NS||0|
|0/1||Normal elk||Oral||NA||123 NS||+7|
*An early version of some of these data is shown in Tables 1, 2 of (7). Since that time more infected animals have been euthanized and the data have been updated. CWD, chronic wasting disease; MD, mule deer; WTD, white-tailed deer; NA, not applicable; NS, no clinical transmissible spongiform encephalopathy signs.
†Number of monkeys in which prion disease developed/number inoculated.
‡Several different inocula were used for this study. Each individual animal was inoculated with 1 inoculum. Detailed descriptions can be found in (7).
§Infectivity titers were determined by using endpoint dilution titer in transgenic deer PrP mice and are listed as 50% infectious dose/gram of brain.
¶The range of incubation periods observed is shown as months postinoculation followed with the average incubation period of the group in parentheses. Monkeys listed as NS did not show any clinical signs compatible with transmissible spongiform encephalopathy.
#Three monkeys from this group are not included in this calculation because they were euthanized before 45 months postinoculation for reasons unrelated to transmissible spongiform encephalopathy disease. The sole remaining animal in this group appeared normal at 108 months postinoculation.
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