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Volume 20, Number 5—May 2014


Chronic Wasting Disease Agents in Nonhuman Primates

Brent RaceComments to Author , Kimberly D. Meade-White, Katie Phillips, James Striebel, Richard Race, and Bruce Chesebro
Author affiliations: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

Main Article

Table 1

Squirrel monkeys inoculated with CWD or squirrel monkey–adapted CWD agents*

Disease incidence† Inoculum‡ Route of inoculation Titer inoculated§ Incubation days, range, (avg)¶ Weight change range, % (avg,%)
13/13 MD-1,2,3 Elk-1,2,3 WTD-1,2 Intracerebral 1.3 × 105-1.0 × 107 33–75 (46) −8 to −43 (−29.5)
11/12# MD-1,3 Elk-1,2,3 WTD-1,2 Oral 9.6 x 107-1.5 × 109 59–107 (68) −8 to −41 (−28)
2/2 SM-CWD Intracerebral NA 23–24 (23.5) −8 to −21 (−14.5)
0/1 Normal elk Intracerebral NA 82 NS 0
0/1 Buffer control Oral NA >108 −6
0/1 Normal elk Oral NA 123 NS +7

*An early version of some of these data is shown in Tables 1, 2 of (7). Since that time more infected animals have been euthanized and the data have been updated. CWD, chronic wasting disease; MD, mule deer; WTD, white-tailed deer; NA, not applicable; NS, no clinical transmissible spongiform encephalopathy signs.
†Number of monkeys in which prion disease developed/number inoculated.
‡Several different inocula were used for this study. Each individual animal was inoculated with 1 inoculum. Detailed descriptions can be found in (7).
§Infectivity titers were determined by using endpoint dilution titer in transgenic deer PrP mice and are listed as 50% infectious dose/gram of brain.
¶The range of incubation periods observed is shown as months postinoculation followed with the average incubation period of the group in parentheses. Monkeys listed as NS did not show any clinical signs compatible with transmissible spongiform encephalopathy.
#Three monkeys from this group are not included in this calculation because they were euthanized before 45 months postinoculation for reasons unrelated to transmissible spongiform encephalopathy disease. The sole remaining animal in this group appeared normal at 108 months postinoculation.

Main Article